PURPOSE OF REVIEW: Efforts have been made to understand how erythroid differentiation is regulated, and recent discoveries have clarified that lineage-specific transcription factor networks are essential for proper differentiation of erythroid cells. The transcription factors GATA1 and GATA2 are involved in such networks that regulate erythroid gene expression. Importantly, expression of Gata1 and Gata2 genes is also under the control of such regulatory networks. The present review is focused on the mechanism of Gata1 and Gata2 gene regulation during erythropoiesis and the physiological significance of their dynamic regulation. RECENT FINDINGS: Gata1 and Gata2 genes are regulated by multiple transcription factors, including their own products GATA1 and GATA2. GATA1 and GATA2 recognize specific regulatory GATA motifs, and their expression levels change dynamically during erythroid differentiation, leading to diversified gene expression during erythropoiesis. SUMMARY: Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes. Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes appeared to be regulated by GATA factor switching.
PURPOSE OF REVIEW: Efforts have been made to understand how erythroid differentiation is regulated, and recent discoveries have clarified that lineage-specific transcription factor networks are essential for proper differentiation of erythroid cells. The transcription factors GATA1 and GATA2 are involved in such networks that regulate erythroid gene expression. Importantly, expression of Gata1 and Gata2 genes is also under the control of such regulatory networks. The present review is focused on the mechanism of Gata1 and Gata2 gene regulation during erythropoiesis and the physiological significance of their dynamic regulation. RECENT FINDINGS:Gata1 and Gata2 genes are regulated by multiple transcription factors, including their own products GATA1 and GATA2. GATA1 and GATA2 recognize specific regulatory GATA motifs, and their expression levels change dynamically during erythroid differentiation, leading to diversified gene expression during erythropoiesis. SUMMARY: Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes. Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes appeared to be regulated by GATA factor switching.
Authors: Xiaozhong Shi; Jai Richard; Katie M Zirbes; Wuming Gong; Gufa Lin; Michael Kyba; Jamie A Thomson; Naoko Koyano-Nakagawa; Daniel J Garry Journal: Dev Biol Date: 2014-02-26 Impact factor: 3.582
Authors: Chellappagounder Thangavel; Cristiano M Gomes; Stephen A Zderic; Elham Javed; Sankar Addya; Jagmohan Singh; Sreya Das; Ruth Birbe; Robert B Den; Satish Rattan; Deepak A Deshpande; Raymond B Penn; Samuel Chacko; Ettickan Boopathi Journal: Am J Pathol Date: 2019-01-30 Impact factor: 4.307
Authors: Jonathan W Snow; Jennifer J Trowbridge; Tohru Fujiwara; Nikla E Emambokus; Jeffrey A Grass; Stuart H Orkin; Emery H Bresnick Journal: PLoS Genet Date: 2010-09-09 Impact factor: 5.917