Literature DB >> 20216163

Prostacyclin in the intensive care setting.

D Dunbar Ivy1.   

Abstract

The prostacyclins-prostanoids were one of the first medications used to treat pulmonary arterial hypertension (PAH). Three prostanoids have been developed to treat PAH: epoprostenol, treprostinil, and iloprost. In the acute setting, experience is growing, using the inhaled forms of these three medications. Inhalation may improve ventilation/perfusion matching, whereas in the intravenous form these medications may cause nonselective pulmonary vasodilation and may worsen ventilation/perfusion matching. Currently, there are no universal recommendations for dosing delivery of inhaled prostanoids to intubated patients in the intensive care unit setting.

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Year:  2010        PMID： 20216163      PMCID： PMC3116926          DOI： 10.1097/PCC.0b013e3181d10845

Source DB:  PubMed          Journal:  Pediatr Crit Care Med        ISSN： 1529-7535            Impact factor:   3.624


  52 in total

1.  Inhaled nitric oxide versus aerosolized iloprost in secondary pulmonary hypertension in children with congenital heart disease: vasodilator capacity and cellular mechanisms.

Authors:  P C Rimensberger; I Spahr-Schopfer; M Berner; E Jaeggi; A Kalangos; B Friedli; M Beghetti
Journal:  Circulation       Date:  2001-01-30       Impact factor: 29.690

2.  Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide.

Authors:  Lisa K Kelly; Nicolas F m Porta; Denise M Goodman; Christopher L Carroll; Robin H Steinhorn
Journal:  J Pediatr       Date:  2002-12       Impact factor: 4.406

Review 3.  Inhaled prostacyclin in the treatment of pulmonary hypertension.

Authors:  M Max; R Rossaint
Journal:  Eur J Pediatr       Date:  1999-12       Impact factor: 3.183

4.  Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial.

Authors:  Nazzareno Galiè; Marc Humbert; Jean-Luc Vachiéry; Carmine Dario Vizza; Meinhard Kneussl; Alessandra Manes; Olivier Sitbon; Adam Torbicki; Marion Delcroix; Robert Naeije; Marius Hoeper; Ari Chaouat; Sophie Morand; Bruno Besse; Gerald Simonneau
Journal:  J Am Coll Cardiol       Date:  2002-05-01       Impact factor: 24.094

5.  Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial.

Authors:  Gerald Simonneau; Robyn J Barst; Nazzareno Galie; Robert Naeije; Stuart Rich; Robert C Bourge; Anne Keogh; Ronald Oudiz; Adaani Frost; Shelmer D Blackburn; James W Crow; Lewis J Rubin
Journal:  Am J Respir Crit Care Med       Date:  2002-03-15       Impact factor: 21.405

6.  Survival in primary pulmonary hypertension: the impact of epoprostenol therapy.

Authors:  Vallerie V McLaughlin; Alicia Shillington; Stuart Rich
Journal:  Circulation       Date:  2002-09-17       Impact factor: 29.690

7.  Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival.

Authors:  Olivier Sitbon; Marc Humbert; Hilario Nunes; Florence Parent; Gilles Garcia; Philippe Hervé; Maurizio Rainisio; Gérald Simonneau
Journal:  J Am Coll Cardiol       Date:  2002-08-21       Impact factor: 24.094

8.  Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.

Authors:  Robert Voswinckel; Frank Reichenberger; Beate Enke; Andre Kreckel; Stefanie Krick; Henning Gall; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Horst Olschewski; Werner Seeger; Hossein A Ghofrani
Journal:  Pulm Pharmacol Ther       Date:  2008-07-09       Impact factor: 3.410

9.  Intravenous iloprost for treatment failure of aerosolised iloprost in pulmonary arterial hypertension.

Authors:  M M Hoeper; E Spiekerkoetter; V Westerkamp; R Gatzke; H Fabel
Journal:  Eur Respir J       Date:  2002-08       Impact factor: 16.671

10.  Inhaled iloprost for severe pulmonary hypertension.

Authors:  Horst Olschewski; Gerald Simonneau; Nazzareno Galiè; Timothy Higenbottam; Robert Naeije; Lewis J Rubin; Sylvia Nikkho; Rudolf Speich; Marius M Hoeper; Jürgen Behr; Jörg Winkler; Olivier Sitbon; Wladimir Popov; H Ardeschir Ghofrani; Alessandra Manes; David G Kiely; Ralph Ewert; Andreas Meyer; Paul A Corris; Marion Delcroix; Miguel Gomez-Sanchez; Harald Siedentop; Werner Seeger
Journal:  N Engl J Med       Date:  2002-08-01       Impact factor: 91.245
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  14 in total

1.  Inhaled Treprostinil Drug Delivery During Mechanical Ventilation and Spontaneous Breathing Using Two Different Nebulizers.

Authors:  Donna K Parker; Shuijie Shen; Jiang Zheng; D Dunbar Ivy; Dave N Crotwell; Justin C Hotz; Robert M DiBlasi
Journal:  Pediatr Crit Care Med       Date:  2017-06       Impact factor: 3.624

Review 2.  Drug treatment of pulmonary hypertension in children.

Authors:  Erika E Vorhies; David Dunbar Ivy
Journal:  Paediatr Drugs       Date:  2014-02       Impact factor: 3.022

Review 3.  Prostanoids and their analogues for the treatment of pulmonary hypertension in neonates.

Authors:  Binoy Shivanna; Sharada Gowda; Stephen E Welty; Keith J Barrington; Mohan Pammi
Journal:  Cochrane Database Syst Rev       Date:  2019-10-01

Review 4.  Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn.

Authors:  Batoule H Majed; Raouf A Khalil
Journal:  Pharmacol Rev       Date:  2012-06-07       Impact factor: 25.468

5.  Effectiveness and safety of inhaled treprostinil for the treatment of pulmonary arterial hypertension in children.

Authors:  Usha Krishnan; Shinichi Takatsuki; Dunbar D Ivy; Jason Kerstein; Michelle Calderbank; Elizabeth Coleman; Erika B Rosenzweig
Journal:  Am J Cardiol       Date:  2012-08-21       Impact factor: 2.778

6.  Use of inhaled iloprost for the management of postoperative pulmonary hypertension in congenital heart surgery patients: review of a transition protocol.

Authors:  Erika E Vorhies; Regine L Caruthers; Howard Rosenberg; Sunkyung Yu; Robert J Gajarski
Journal:  Pediatr Cardiol       Date:  2014-05-29       Impact factor: 1.655

Review 7.  Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Pulmonary Hypertension.

Authors:  John S Kim; Julia McSweeney; Joanne Lee; Dunbar Ivy
Journal:  Pediatr Crit Care Med       Date:  2016-03       Impact factor: 3.624

Review 8.  Drug Treatment of Pulmonary Hypertension in Children.

Authors:  Catherine M Avitabile; Erika E Vorhies; David Dunbar Ivy
Journal:  Paediatr Drugs       Date:  2020-04       Impact factor: 3.022

Review 9.  Current challenges in pediatric pulmonary hypertension.

Authors:  Shinichi Takatsuki; David Dunbar Ivy
Journal:  Semin Respir Crit Care Med       Date:  2013-09-13       Impact factor: 3.119

10.  Acute pulmonary vasodilator testing with inhaled treprostinil in children with pulmonary arterial hypertension.

Authors:  Shinichi Takatsuki; Donna K Parker; Aimee K Doran; Robert H Friesen; D Dunbar Ivy
Journal:  Pediatr Cardiol       Date:  2012-11-27       Impact factor: 1.655
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