Literature DB >> 20215864

The molecular pathogenesis of Ewing's sarcoma.

Carlos Mackintosh1, Juan Madoz-Gúrpide, Jose Luis Ordóñez, Daniel Osuna, David Herrero-Martín.   

Abstract

Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.

Entities:  

Mesh：

Year:  2010        PMID： 20215864     DOI： 10.4161/cbt.9.9.11511

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  34 in total

1.  Primitive Neuroectodermal Tumor (PNET) of the Small Bowel in a Young Adult with Lower Gastrointestinal Bleeding.

Authors:  Mario Rodarte-Shade; Rene Palomo-Hoil; Josafat Vazquez; Adriana Ancer; Natalia Vilches; Juan Pablo Flores-Gutierrez; Melissa Sierra; Ulises Garza-Serna
Journal:  J Gastrointest Cancer       Date:  2012-09

2.  Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.

Authors:  Peter C Hollenhorst; Mary W Ferris; Megan A Hull; Heejoon Chae; Sun Kim; Barbara J Graves
Journal:  Genes Dev       Date:  2011-10-15       Impact factor: 11.361

3.  Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.

Authors:  David Schirmer; Thomas G P Grünewald; Richard Klar; Oxana Schmidt; Dirk Wohlleber; Rebeca Alba Rubío; Wolfgang Uckert; Uwe Thiel; Felix Bohne; Dirk H Busch; Angela M Krackhardt; Stefan Burdach; Günther H S Richter
Journal:  Oncoimmunology       Date:  2016-04-25       Impact factor: 8.110

4.  RAS/ERK pathway transcriptional regulation through ETS/AP-1 binding sites.

Authors:  Peter C Hollenhorst
Journal:  Small GTPases       Date:  2012-06-01

5.  Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG.

Authors:  Andreas Pettersson; Rosina T Lis; Allison Meisner; Richard Flavin; Edward C Stack; Michelangelo Fiorentino; Stephen Finn; Rebecca E Graff; Kathryn L Penney; Jennifer R Rider; Elizabeth J Nuttall; Neil E Martin; Howard D Sesso; Michael Pollak; Meir J Stampfer; Philip W Kantoff; Edward L Giovannucci; Massimo Loda; Lorelei A Mucci
Journal:  J Natl Cancer Inst       Date:  2013-11-30       Impact factor: 13.506

6.  Ewing's sarcoma: overcoming the therapeutic plateau.

Authors:  Vivek Subbiah; Razelle Kurzrock
Journal:  Discov Med       Date:  2012-06       Impact factor: 2.970

7.  Bioengineered human tumor within a bone niche.

Authors:  Aranzazu Villasante; Alessandro Marturano-Kruik; Gordana Vunjak-Novakovic
Journal:  Biomaterials       Date:  2014-04-18       Impact factor: 12.479

8.  Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.

Authors:  Thomas G P Grünewald; Virginie Bernard; Pascale Gilardi-Hebenstreit; Virginie Raynal; Didier Surdez; Marie-Ming Aynaud; Olivier Mirabeau; Florencia Cidre-Aranaz; Franck Tirode; Sakina Zaidi; Gaëlle Perot; Anneliene H Jonker; Carlo Lucchesi; Marie-Cécile Le Deley; Odile Oberlin; Perrine Marec-Bérard; Amélie S Véron; Stephanie Reynaud; Eve Lapouble; Valentina Boeva; Thomas Rio Frio; Javier Alonso; Smita Bhatia; Gaëlle Pierron; Geraldine Cancel-Tassin; Olivier Cussenot; David G Cox; Lindsay M Morton; Mitchell J Machiela; Stephen J Chanock; Patrick Charnay; Olivier Delattre
Journal:  Nat Genet       Date:  2015-07-27       Impact factor: 38.330

Review 9.  Optimal management of Ewing sarcoma family of tumors: recent developments in systemic therapy.

Authors:  Cormac Owens; Lesleigh S Abbott; Abha A Gupta
Journal:  Paediatr Drugs       Date:  2013-12       Impact factor: 3.022

10.  Ewing Sarcoma: influence of TP53 Arg72Pro and MDM2 T309G SNPs.

Authors:  Helena S Thurow; Fernando P Hartwig; Clarice S Alho; Deborah S B S Silva; Rafael Roesler; Ana Lucia Abujamra; Caroline Brunetto de Farias; Algemir Lunardi Brunetto; Bernardo L Horta; Odir A Dellagostin; Tiago Collares; Fabiana K Seixas
Journal:  Mol Biol Rep       Date:  2013-05-10       Impact factor: 2.316
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