Literature DB >> 20213314

Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide.

Byung Ryong Lee1, Yeom Pyo Lee, Dae Won Kim, Ha Yong Song, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Kwang Jae Lee, Kyung Hee Kim, Jin Ho Joo, Hun Ju Ham, Jang Hyun Hur, Sung-Woo Cho, Kyu Hyung Han, Kil Soo Lee, Jinseu Park, Won Sik Eum, Soo Young Choi.   

Abstract

The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic beta-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic beta-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.

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Year:  2010        PMID： 20213314     DOI： 10.1007/s10059-010-0044-9

Source DB:  PubMed          Journal:  Mol Cells        ISSN： 1016-8478            Impact factor:   5.034


  8 in total

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Journal:  Mol Cells       Date:  2011-02-10       Impact factor: 5.034

2.  Pleurotus tuber-regium Polysaccharides Attenuate Hyperglycemia and Oxidative Stress in Experimental Diabetic Rats.

Authors:  Hui-Yu Huang; Mallikarjuna Korivi; Ying-Ying Chaing; Ting-Yi Chien; Ying-Chieh Tsai
Journal:  Evid Based Complement Alternat Med       Date:  2012-08-30       Impact factor: 2.629

3.  The antioxidative effects of acidic-, alkalic-, and enzymatic-extractable mycelium zinc polysaccharides by Pleurotus djamor on liver and kidney of streptozocin-induced diabetic mice.

Authors:  Jianjun Zhang; Guangyuan Meng; Chen Zhang; Lin Lin; Nuo Xu; Min Liu; Fangyuan Cui; Le Jia
Journal:  BMC Complement Altern Med       Date:  2015-12-18       Impact factor: 3.659

Review 4.  Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans.

Authors:  Mendel Friedman
Journal:  Foods       Date:  2016-11-29

5.  Microencapsulation and the Characterization of Polyherbal Formulation (PHF) Rich in Natural Polyphenolic Compounds.

Authors:  Syed Ammar Hussain; Ahsan Hameed; Yusuf Nazir; Tahira Naz; Yang Wu; Hafiz Ansar Rasul Suleria; Yuanda Song
Journal:  Nutrients       Date:  2018-06-28       Impact factor: 5.717

6.  The effects of hot air-dried white button mushroom powder on glycemic indices, lipid profile, inflammatory biomarkers and total antioxidant capacity in patients with type-2 diabetes mellitus: A randomized controlled trial.

Authors:  Hadiseh Hashemi Yusefabad; Seyed Ahmad Hosseini; Mehrnoosh Zakerkish; Bahman Cheraghian; Meysam Alipour
Journal:  J Res Med Sci       Date:  2022-07-29       Impact factor: 1.985

7.  Analysis of genetic diversity among Chinese Cyclocybe chaxingu strains using ISSR and SRAP markers.

Authors:  Jin-Hao Liu; Fang-Hui Ding; Hai-Yan Song; Ming-Hui Chen; Dian-Ming Hu
Journal:  PeerJ       Date:  2022-09-29       Impact factor: 3.061

8.  Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice.

Authors:  Chen Zhang; Juan Li; Chunlong Hu; Jing Wang; Jianjun Zhang; Zhenzhen Ren; Xinling Song; Le Jia
Journal:  Sci Rep       Date:  2017-09-07       Impact factor: 4.379
  8 in total

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