The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards different double-stranded oligonucleotides was probed by electrospray ionisation mass spectrometry and compared with that of the widely used platinum-based chemotherapeutics cisplatin, carboplatin and oxaliplatin. It was found that the extent of adduct formation decreased in the following order: cisplatin > oxaliplatin > NAMI-A > RAPTA-T > carboplatin > KP1019. In addition to the characterisation of the adducts formed with the DNA models, the binding sites of the metallodrugs on the oligonucleotides were elucidated employing top-down tandem mass spectrometry and were found to be similar for all the metallodrugs studied, irrespective of the sequence of the oligonucleotide. A strong preference for guanine residues was established.
The binding of the an class="Chemical">ruthenium-based antian class="Disease">cancer drug candidates KP1019, NAMI-A and RAPTA-T towards different double-stranded oligonucleotides was probed by electrospray ionisation mass spectrometry and compared with that of the widely used platinum-based chemotherapeutics cisplatin, carboplatin and oxaliplatin. It was found that the extent of adduct formation decreased in the following order: cisplatin > oxaliplatin > NAMI-A > RAPTA-T > carboplatin > KP1019. In addition to the characterisation of the adducts formed with the DNA models, the binding sites of the metallodrugs on the oligonucleotides were elucidated employing top-down tandem mass spectrometry and were found to be similar for all the metallodrugs studied, irrespective of the sequence of the oligonucleotide. A strong preference for guanine residues was established.
Authors: Michael Groessl; Erwin Reisner; Christian G Hartinger; Rene Eichinger; Olga Semenova; Andrei R Timerbaev; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler Journal: J Med Chem Date: 2007-04-03 Impact factor: 7.446
Authors: Alexander E Egger; Christian G Hartinger; Hisham Ben Hamidane; Yury O Tsybin; Bernhard K Keppler; Paul J Dyson Journal: Inorg Chem Date: 2008-10-24 Impact factor: 5.165
Authors: Rebecca H Wills; Abraha Habtemariam; Andrea F Lopez-Clavijo; Mark P Barrow; Peter J Sadler; Peter B O'Connor Journal: J Am Soc Mass Spectrom Date: 2014-02-01 Impact factor: 3.109
Authors: Adrien Nyakas; Lorenz C Blum; Silvan R Stucki; Jean-Louis Reymond; Stefan Schürch Journal: J Am Soc Mass Spectrom Date: 2012-12-21 Impact factor: 3.109
Authors: Alvin A Holder; Patrick Taylor; Anthony R Magnusen; Erick T Moffett; Kyle Meyer; Yiling Hong; Stuart E Ramsdale; Michelle Gordon; Javelyn Stubbs; Luke A Seymour; Dhiraj Acharya; Ralph T Weber; Paul F Smith; G Charles Dismukes; Ping Ji; Laura Menocal; Fengwei Bai; Jennie L Williams; Donald M Cropek; William L Jarrett Journal: Dalton Trans Date: 2013-09-07 Impact factor: 4.390