BACKGROUND: Endurance exercise is frequently associated with cardiac troponin (cTn) concentrations, otherwise corresponding to minor myocardial infarction. However, research on the underlying mechanisms has been limited because of assay restraints in the low concentration range. METHODS AND RESULTS: Using the pre-commercial, highly sensitive hs-cTnT assay, cTnT concentrations were measured in samples from recreational runners obtained before and after running 5 km (trained, n = 43/untrained, n = 122), 15 km (n = 38), 21 km (n = 10), and 42 km (n = 85) (all trained). The percentage of runners with elevated cTnT concentrations after the run increased with running distance (0, 11, 13, 40, and 86%), in contrast to NT-proBNP (2, 7, 0, 0, 5). Median (IQR) cTnT post-run concentrations were 0.004 microg/L (0.003), 0.006 microg/L (0.008), 0.010 microg/L (0.006), 0.014 microg/L (0.019), and 0.030 microg/L (0.029), respectively. CONCLUSIONS: We found, using a novel hs-cTnT assay, the distance of recreational competitive running to be positively related to asymptomatic increases in cTnT post-run concentrations. In contrast, NT-proBNP showed no increase. In addition, the data indicated that a relatively short running distance of 5 km resulted in cTnT release of untrained participants, in contrast to trained participants, which underlines the necessity of sufficient training. Further effort is needed to clarify the significance of exercise-induced cardiac biomarker elevations.
BACKGROUND: Endurance exercise is frequently associated with cardiac troponin (cTn) concentrations, otherwise corresponding to minor myocardial infarction. However, research on the underlying mechanisms has been limited because of assay restraints in the low concentration range. METHODS AND RESULTS: Using the pre-commercial, highly sensitive hs-cTnT assay, cTnT concentrations were measured in samples from recreational runners obtained before and after running 5 km (trained, n = 43/untrained, n = 122), 15 km (n = 38), 21 km (n = 10), and 42 km (n = 85) (all trained). The percentage of runners with elevated cTnT concentrations after the run increased with running distance (0, 11, 13, 40, and 86%), in contrast to NT-proBNP (2, 7, 0, 0, 5). Median (IQR) cTnT post-run concentrations were 0.004 microg/L (0.003), 0.006 microg/L (0.008), 0.010 microg/L (0.006), 0.014 microg/L (0.019), and 0.030 microg/L (0.029), respectively. CONCLUSIONS: We found, using a novel hs-cTnT assay, the distance of recreational competitive running to be positively related to asymptomatic increases in cTnT post-run concentrations. In contrast, NT-proBNP showed no increase. In addition, the data indicated that a relatively short running distance of 5 km resulted in cTnT release of untrained participants, in contrast to trained participants, which underlines the necessity of sufficient training. Further effort is needed to clarify the significance of exercise-induced cardiac biomarker elevations.
Authors: Elizabeth B Fortescue; Andrew Y Shin; David S Greenes; Rebekah C Mannix; Suneet Agarwal; Brian J Feldman; Manish I Shah; Nader Rifai; Michael J Landzberg; Jane W Newburger; Christopher S D Almond Journal: Ann Emerg Med Date: 2006-12-04 Impact factor: 5.721
Authors: Barry J Maron; Paul D Thompson; Michael J Ackerman; Gary Balady; Stuart Berger; David Cohen; Robert Dimeff; Pamela S Douglas; David W Glover; Adolph M Hutter; Michael D Krauss; Martin S Maron; Matthew J Mitten; William O Roberts; James C Puffer Journal: Circulation Date: 2007-03-12 Impact factor: 29.690
Authors: Fred S Apple; Alan H B Wu; Allan S Jaffe; Mauro Panteghini; Robert H Christenson; Christopher P Cannon; Gary Francis; Robert L Jesse; David A Morrow; L Kristen Newby; Alan B Storrow; W H Wilson Tang; Franca Pagani; Jillian Tate; Jordi Ordonez-Llanos; Johannes Mair Journal: Circulation Date: 2007-07-14 Impact factor: 29.690
Authors: Natalie Middleton; Keith George; Greg Whyte; David Gaze; Paul Collinson; Rob Shave Journal: J Am Coll Cardiol Date: 2008-11-25 Impact factor: 24.094
Authors: Jillian R Tate; Wendy Ferguson; Renze Bais; Karam Kostner; Thomas Marwick; Andrew Carter Journal: Ann Clin Biochem Date: 2008-05 Impact factor: 2.057
Authors: Jürgen Scharhag; Markus Herrmann; Axel Urhausen; Michaela Haschke; Wolfgang Herrmann; Wilfried Kindermann Journal: Am Heart J Date: 2005-12 Impact factor: 4.749
Authors: Enrique Serrano-Ostáriz; Alejandro Legaz-Arrese; José Luis Terreros-Blanco; Marta López-Ramón; Daniel Cremades-Arroyos; Luis Enrique Carranza-García; Silvia Izquierdo-Alvarez; Silvia Alvarez-Izquierdo; Pilar Bocos-Terraz; Pilar Boscos-Terraz Journal: Clin J Sport Med Date: 2009-07 Impact factor: 3.638
Authors: M H M Hessel; D E Atsma; E J M van der Valk; W H Bax; M J Schalij; A van der Laarse Journal: Pflugers Arch Date: 2007-10-02 Impact factor: 3.657
Authors: Marco Metra; Luca Bettari; Franca Pagani; Valentina Lazzarini; Carlo Lombardi; Valentina Carubelli; Graziella Bonetti; Silvia Bugatti; Giovanni Parrinello; Luigi Caimi; G Michael Felker; Livio Dei Cas Journal: Clin Res Cardiol Date: 2012-03-10 Impact factor: 5.460
Authors: Anke Neukamm; Gunnar Einvik; Arne Didrik Høiseth; Vidar Søyseth; Nils Henrik Holmedahl; Natalia Kononova; Torbjørn Omland Journal: BMC Pulm Med Date: 2016-11-25 Impact factor: 3.317
Authors: Sofia Nyberg; Edvard Gerring; Solveig Gjellan; Marta Vergara; Torbjörn Lindström; Fredrik H Nystrom Journal: Ups J Med Sci Date: 2013-08-27 Impact factor: 2.384