PURPOSE: To elucidate the effect of IFN-α treatment on tumor growth and metastasis of hepatocellular carcinoma (HCC). METHODS: IFN-α administration was conducted in nude mice using an orthotopic implantation model of human HCC, and the key molecular markers in the IFN-α treatment was detected by immunohistochemistry staining and PCR array. RESULTS: Up to 12 weeks of IFN-α treatment significantly suppressed tumor growth of HCC, but relatively increased the number of circulating tumor cells, which might be due to the enhanced tumor hypoxia as well as up-regulation of metastasis-related genes, such as HIF-1α, c-met, u-PA, PDGF-A, and IL-8. However, IFN-α had no direct effect on migration and invasion of HCC cells. CONCLUSIONS: IFN-α has janus face of consistently suppressing HCC growth, however, promoting tumor metastasis capacity, which is of clinical indication for the scientific administration of IFN-α and the similar antiangiogenesis drugs for their dual effect on tumor growth and metastasis.
PURPOSE: To elucidate the effect of IFN-α treatment on tumor growth and metastasis of hepatocellular carcinoma (HCC). METHODS: IFN-α administration was conducted in nude mice using an orthotopic implantation model of human HCC, and the key molecular markers in the IFN-α treatment was detected by immunohistochemistry staining and PCR array. RESULTS: Up to 12 weeks of IFN-α treatment significantly suppressed tumor growth of HCC, but relatively increased the number of circulating tumor cells, which might be due to the enhanced tumor hypoxia as well as up-regulation of metastasis-related genes, such as HIF-1α, c-met, u-PA, PDGF-A, and IL-8. However, IFN-α had no direct effect on migration and invasion of HCC cells. CONCLUSIONS: IFN-α has janus face of consistently suppressing HCC growth, however, promoting tumor metastasis capacity, which is of clinical indication for the scientific administration of IFN-α and the similar antiangiogenesis drugs for their dual effect on tumor growth and metastasis.
Authors: Gregory Bix; Remedios Castello; Michelle Burrows; Jason J Zoeller; Michelle Weech; Rex A Iozzo; Christopher Cardi; Mathew L Thakur; Christopher A Barker; Kevin Camphausen; Renato V Iozzo Journal: J Natl Cancer Inst Date: 2006-11-15 Impact factor: 13.506
Authors: W Gregory Roberts; Pamela M Whalen; Erik Soderstrom; Garrett Moraski; Joseph P Lyssikatos; Huifen-F Wang; Beth Cooper; Deborah A Baker; Douglas Savage; Deepak Dalvie; James A Atherton; Sherry Ralston; Ruby Szewc; John C Kath; Jing Lin; Cathy Soderstrom; George Tkalcevic; Bruce D Cohen; Vince Pollack; Wayne Barth; Will Hungerford; Ethan Ung Journal: Cancer Res Date: 2005-02-01 Impact factor: 12.701
Authors: Danielle A Murphy; Sosina Makonnen; Wiem Lassoued; Michael D Feldman; Christopher Carter; William M F Lee Journal: Am J Pathol Date: 2006-11 Impact factor: 4.307
Authors: Chung Mau Lo; Chi Leung Liu; See Ching Chan; Chi Ming Lam; Ronnie T P Poon; Irene O L Ng; Sheung Tat Fan; John Wong Journal: Ann Surg Date: 2007-06 Impact factor: 12.969