Literature DB >> 20212464

GSK/Sirtris compounds dogged by assay artifacts.

Charlie Schmidt.   

Abstract

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Year:  2010        PMID： 20212464     DOI： 10.1038/nbt0310-185

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  5 in total

1.  GSK moves on Sirtris.

Authors:  Douglas Sipp
Journal:  Nat Biotechnol       Date:  2008-06       Impact factor: 54.908

2.  A mid-life crisis for aging theory.

Authors:  Ken Garber
Journal:  Nat Biotechnol       Date:  2008-04       Impact factor: 54.908

3.  Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.

Authors:  Matt Kaeberlein; R Wilson Powers; Kristan K Steffen; Eric A Westman; Di Hu; Nick Dang; Emily O Kerr; Kathryn T Kirkland; Stanley Fields; Brian K Kennedy
Journal:  Science       Date:  2005-11-18       Impact factor: 47.728

4.  Substrate-specific activation of sirtuins by resveratrol.

Authors:  Matt Kaeberlein; Thomas McDonagh; Birgit Heltweg; Jeffrey Hixon; Eric A Westman; Seth D Caldwell; Andrew Napper; Rory Curtis; Peter S DiStefano; Stanley Fields; Antonio Bedalov; Brian K Kennedy
Journal:  J Biol Chem       Date:  2005-01-31       Impact factor: 5.157

5.  Resveratrol is not a direct activator of SIRT1 enzyme activity.

Authors:  Dirk Beher; John Wu; Suzanne Cumine; Ki Won Kim; Shu-Chen Lu; Larissa Atangan; Minghan Wang
Journal:  Chem Biol Drug Des       Date:  2009-10-20       Impact factor: 2.817
  5 in total
  13 in total

1.  Pleiotropic mechanisms facilitated by resveratrol and its metabolites.

Authors:  Barbara Calamini; Kiira Ratia; Michael G Malkowski; Muriel Cuendet; John M Pezzuto; Bernard D Santarsiero; Andrew D Mesecar
Journal:  Biochem J       Date:  2010-07-15       Impact factor: 3.857

2.  SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.

Authors:  Min Pan; Hua Yuan; Michael Brent; Emily Chen Ding; Ronen Marmorstein
Journal:  J Biol Chem       Date:  2011-12-07       Impact factor: 5.157

3.  Heterogeneity versus homogeneity of multiple sclerosis.

Authors:  Fumitaka Sato; Nicholas E Martinez; Seiichi Omura; Ikuo Tsunoda
Journal:  Expert Rev Clin Immunol       Date:  2011-03       Impact factor: 4.473

Review 4.  Catalysis and mechanistic insights into sirtuin activation.

Authors:  Kristin E Dittenhafer-Reed; Jessica L Feldman; John M Denu
Journal:  Chembiochem       Date:  2010-11-09       Impact factor: 3.164

Review 5.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

Authors:  Maria M Mihaylova; Reuben J Shaw
Journal:  Nat Cell Biol       Date:  2011-09-02       Impact factor: 28.824

6.  Resveratrol exacerbates both autoimmune and viral models of multiple sclerosis.

Authors:  Fumitaka Sato; Nicholas E Martinez; Maira Shahid; John W Rose; Noel G Carlson; Ikuo Tsunoda
Journal:  Am J Pathol       Date:  2013-10-01       Impact factor: 4.307

Review 7.  The ways and means that fine tune Sirt1 activity.

Authors:  Javier R Revollo; Xiaoling Li
Journal:  Trends Biochem Sci       Date:  2013-02-07       Impact factor: 13.807

8.  Treating aging: progress toward dietary restriction mimetics.

Authors:  Filipe Cabreiro; David Gems
Journal:  F1000 Biol Rep       Date:  2010-10-21

9.  Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation.

Authors:  Mengmeng Wang; Amanda K Kussrow; Mireia Fernandez Ocana; Jeffrey R Chabot; Christopher S Lepsy; Darryl J Bornhop; Denise M O'Hara
Journal:  Br J Pharmacol       Date:  2016-11-30       Impact factor: 8.739

Review 10.  Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets.

Authors:  Uzma Saqib; Tanya T Kelley; Siva K Panguluri; Dongfang Liu; Rajkumar Savai; Mirza S Baig; Stephan C Schürer
Journal:  Front Pharmacol       Date:  2018-10-24       Impact factor: 5.810
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