OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with human leukocyte antigen (HLA) class I and II antigens. METHODS: HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated. RESULTS: Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types. CONCLUSIONS: Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.
OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with humanleukocyte antigen (HLA) class I and II antigens. METHODS:HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated. RESULTS: Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types. CONCLUSIONS: Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.
Authors: Lotte Vlam; W-Ludo van der Pol; Elisabeth A Cats; Dirk C Straver; Sanneke Piepers; Hessel Franssen; Leonard H van den Berg Journal: Nat Rev Neurol Date: 2011-11-22 Impact factor: 42.937
Authors: Lotte Vlam; Leonard H van den Berg; Elisabeth A Cats; Sanne Piepers; W-Ludo van der Pol Journal: J Clin Immunol Date: 2012-09-02 Impact factor: 8.317
Authors: Elisabeth A Cats; Anne Suzanne Bertens; Jan H Veldink; Leonard H van den Berg; W Ludo van der Pol Journal: J Neurol Date: 2011-11-23 Impact factor: 4.849
Authors: Jeroen W Bos; Ewout J N Groen; Renske I Wadman; Chantall A D Curial; Naomi N Molleman; Marinka Zegers; Paul W J van Vught; Reinier Snetselaar; Raymon Vijzelaar; W Ludo van der Pol; Leonard H van den Berg Journal: Neurol Genet Date: 2021-06-22