Literature DB >> 20211890

Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus.

Esteban C Nannini1, Martin E Stryjewski, Kavindra V Singh, Tom H Rude, G Ralph Corey, Vance G Fowler, Barbara E Murray.   

Abstract

Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.

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Year:  2010        PMID： 20211890      PMCID： PMC2863656          DOI： 10.1128/AAC.01325-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Effect of inoculum and of beta-lactamase on the anti-staphylococcal activity of thirteen penicillins and cephalosporins.

Authors:  L D Sabath; C Garner; C Wilcox; M Finland
Journal:  Antimicrob Agents Chemother       Date:  1975-09       Impact factor: 5.191

2.  In vitro susceptibility of Staphylococcus aureus towards amoxycillin-clavulanic acid, penicillin-clavulanic acid, dicloxacillin and cefuroxime.

Authors:  Robert Skov; Niels Frimodt-Møller; Frank Espersen
Journal:  APMIS       Date:  2002-08       Impact factor: 3.205

3.  Ceftriaxone therapy for staphylococcal osteomyelitis: a review.

Authors:  B J Guglielmo; A D Luber; D Paletta; R A Jacobs
Journal:  Clin Infect Dis       Date:  2000-01       Impact factor: 9.079

4.  Penicillinase production in Staphylococcus aureus strains of clinical importance.

Authors:  V T Rosdahl
Journal:  Dan Med Bull       Date:  1986-08

5.  Clinical experiences with cefazolin and other cephalosporins in bacterial endocarditis.

Authors:  E L Quinn; D Pohlod; T Madhavan; K Burch; E Fisher; F Cox
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

6.  Unsuccessful treatment of staphylococcal endocarditis with cefazolin.

Authors:  R E Bryant; R H Alford
Journal:  JAMA       Date:  1977-02-07       Impact factor: 56.272

7.  Relapse of type A beta-lactamase-producing Staphylococcus aureus native valve endocarditis during cefazolin therapy: revisiting the issue.

Authors:  Esteban C Nannini; Kavindra V Singh; Barbara E Murray
Journal:  Clin Infect Dis       Date:  2003-10-01       Impact factor: 9.079

8.  Use of a heavy inoculum in the in vitro evaluation of the anti-staphylococcal activity of 19 cephalosporins.

Authors:  M Laverdiere; D Welter; L D Sabath
Journal:  Antimicrob Agents Chemother       Date:  1978-04       Impact factor: 5.191

9.  Importance of beta-lactamase inactivation in treatment of experimental endocarditis caused by Staphylococcus aureus.

Authors:  P L Goldman; R G Petersdorf
Journal:  J Infect Dis       Date:  1980-03       Impact factor: 5.226

10.  Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: frequency and possible cause of cefazolin treatment failure.

Authors:  Esteban C Nannini; Martin E Stryjewski; Kavindra V Singh; Agathe Bourgogne; Tom H Rude; G Ralph Corey; Vance G Fowler; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2009-06-01       Impact factor: 5.191
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  16 in total

1.  A retrospective comparison of ceftriaxone versus oxacillin for osteoarticular infections due to methicillin-susceptible Staphylococcus aureus.

Authors:  Brent W Wieland; Jodie R Marcantoni; Kerry M Bommarito; David K Warren; Jonas Marschall
Journal:  Clin Infect Dis       Date:  2011-12-05       Impact factor: 9.079

2.  Inoculum effect of β-lactam antibiotics.

Authors:  Justin R Lenhard; Zackery P Bulman
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

3.  Tolerability of cefazolin after immune-mediated hypersensitivity reactions to nafcillin in the outpatient setting.

Authors:  Kimberly G Blumenthal; Ilan Youngster; Erica S Shenoy; Aleena Banerji; Sandra B Nelson
Journal:  Antimicrob Agents Chemother       Date:  2014-03-17       Impact factor: 5.191

4.  Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.

Authors:  J Chase McNeil; Lauren M Sommer; Mary Boyle; Patrick Hogan; Jesus G Vallejo; Kristina G Hultén; Anthony R Flores; Sheldon L Kaplan; Stephanie Fritz
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

5.  Prophylaxis with teicoplanin and cefuroxime reduces the rate of prosthetic joint infection after primary arthroplasty.

Authors:  Eduard Tornero; Sebastian García-Ramiro; Juan C Martínez-Pastor; Guillem Bori; Jordi Bosch; Laura Morata; Marta Sala; Misericordia Basora; Josep Mensa; Alex Soriano
Journal:  Antimicrob Agents Chemother       Date:  2014-11-17       Impact factor: 5.191

6.  Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis.

Authors:  Kavindra V Singh; Truc T Tran; Esteban C Nannini; Vincent H Tam; Cesar A Arias; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

7.  Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations.

Authors:  Rachel L Soon; Justin R Lenhard; Zackery P Bulman; Patricia N Holden; Pamela Kelchlin; Judith N Steenbergen; Lawrence V Friedrich; Alan Forrest; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

8.  Comparative evaluation of the tolerability of cefazolin and nafcillin for treatment of methicillin-susceptible Staphylococcus aureus infections in the outpatient setting.

Authors:  Ilan Youngster; Erica S Shenoy; David C Hooper; Sandra B Nelson
Journal:  Clin Infect Dis       Date:  2014-04-29       Impact factor: 9.079

9.  Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model.

Authors:  Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2012-03-26       Impact factor: 5.191

10.  Prevalence of blaZ gene types and the cefazolin inoculum effect among methicillin-susceptible Staphylococcus aureus blood isolates and their association with multilocus sequence types and clinical outcome.

Authors:  Y P Chong; S-J Park; E S Kim; K-M Bang; M-N Kim; S-H Kim; S-O Lee; S-H Choi; J-Y Jeong; J H Woo; Y S Kim
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-09-12       Impact factor: 3.267
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