| Literature DB >> 20211708 |
Debora Gazzana Flores1, Luise Meurer, Augusto Frantz Uberti, Bruno R Macedo, Guido Lenz, Algemir Lunardi Brunetto, Gilberto Schwartsmann, Rafael Roesler.
Abstract
The gastrin-releasing peptide receptor (GRPR) has been put forward as a therapeutic target in brain tumors. Here we evaluated GRPR presence in glioma specimens from patients as well as in normal human brain samples. Sections of paraffin-embedded brain tumors and non-neoplastic control brain tissue were analyzed with immunohistochemistry for GRPR content. Digital image analysis revealed that 100% of glioma samples were GRPR-positive, with a mean index of 4972 pixels. In normal brain tissue, GRPR was detected in neurons, but not glial cells. This study is the first to confirm the presence of GRPR in human glioma specimens and normal human neurons. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20211708 DOI： 10.1016/j.brainresbull.2010.02.014
Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077