Literature DB >> 20211511

Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.

Ozair Alam1, Pooja Mullick, S P Verma, Sadaf J Gilani, Suroor A Khan, Nadeem Siddiqui, Waquar Ahsan.   

Abstract

A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20211511     DOI： 10.1016/j.ejmech.2010.02.031

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A.

Authors:  Young Han Lee; Jihyun Park; Seunghyun Ahn; Youngshim Lee; Junho Lee; Soon Young Shin; Dongsoo Koh; Yoongho Lim
Journal:  Daru       Date:  2019-06-01       Impact factor: 3.117

2.  (E)-2-[1-(1-Benzothio-phen-2-yl)ethyl-idene]-N-phenyl-hydrazinecarboxamide.

Authors:  Safa'a Faris Kayed; Yang Farina; Jim Simpson; Ibrahim Baba
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-20

3.  (2E)-2-[(2-Hy-droxy-4-meth-oxy-phen-yl)(phen-yl)methyl-idene]-N-phenyl-hydrazinecarboxamide dimethyl-formamide monosolvate.

Authors:  C F Annie; Jinsa Mary Jacob; M Sithambaresan; M R Prathapachandra Kurup
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-04-25

4.  Anticonvulsant profiles of certain new 6-aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones.

Authors:  Mohamed N Aboul-Enein; Aida A El-Azzouny; Mohamed I Attia; Yousreya A Maklad; Mona E Aboutabl; Fatma Ragab; Walaa H A Abd El-Hamid
Journal:  Int J Mol Sci       Date:  2014-09-23       Impact factor: 5.923

5.  Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives.

Authors:  Hatem A Abuelizz; Rabab El Dib; Mohamed Marzouk; El-Hassane Anouar; Yousreya A Maklad; Hanan N Attia; Rashad Al-Salahi
Journal:  Molecules       Date:  2017-06-30       Impact factor: 4.411

6.  Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.

Authors:  Mohamed I Attia; Mohamed N Aboul-Enein; Aida A El-Azzouny; Yousreya A Maklad; Hazem A Ghabbour
Journal:  ScientificWorldJournal       Date:  2014-01-12
  6 in total

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