| Literature DB >> 20211128 |
Hwan-Ching Tai1, Erin M Schuman.
Abstract
Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome. (c) 2010 Elsevier Inc. All rights reserved.Entities:
Year: 2010 PMID： 20211128 DOI： 10.1016/j.cell.2010.02.019
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582