OBJECTIVE: To assess the acceptability of a daily pill for prevention of HIV acquisition among 400 Ghanaian women in the oral tenofovir disoproxil fumarate (TDF) clinical trial. METHODS: Structured questionnaires were conducted with women enrolled in the trial at enrollment and at each of the 12 monthly follow-up visits. Growth curve analysis was used to examine adherence patterns over time. Qualitative interviews were carried out with a subsample of the clinical trial population, and thematic analysis was applied to these data. RESULTS: Overall, acceptability of the pill was good. Adherence remained > 82% throughout the 12-month trial. Consistent access to the pill and study assignment were both associated with adherence. Most reported problems diminished over time as women became accustomed to the pill and developed strategies to incorporate pill taking into their daily routines. CONCLUSIONS: If daily preexposure prophylaxis (PrEP) for HIV is found to be efficacious and has as few physical side effects as TDF, acceptability of this method among women in the study population may not be problematic. However, future studies must develop better acceptability measures, in order to more fully address the relationship among adherence, safety, and effectiveness.
OBJECTIVE: To assess the acceptability of a daily pill for prevention of HIV acquisition among 400 Ghanaian women in the oral tenofovir disoproxil fumarate (TDF) clinical trial. METHODS: Structured questionnaires were conducted with women enrolled in the trial at enrollment and at each of the 12 monthly follow-up visits. Growth curve analysis was used to examine adherence patterns over time. Qualitative interviews were carried out with a subsample of the clinical trial population, and thematic analysis was applied to these data. RESULTS: Overall, acceptability of the pill was good. Adherence remained > 82% throughout the 12-month trial. Consistent access to the pill and study assignment were both associated with adherence. Most reported problems diminished over time as women became accustomed to the pill and developed strategies to incorporate pill taking into their daily routines. CONCLUSIONS: If daily preexposure prophylaxis (PrEP) for HIV is found to be efficacious and has as few physical side effects as TDF, acceptability of this method among women in the study population may not be problematic. However, future studies must develop better acceptability measures, in order to more fully address the relationship among adherence, safety, and effectiveness.
Authors: Whitney S Rice; Kristi L Stringer; Maira Sohail; Kaylee B Crockett; Ghislaine C Atkins; Kachina Kudroff; D Scott Batey; Joshua Hicks; Janet M Turan; Michael J Mugavero; Bulent Turan Journal: AIDS Behav Date: 2019-11
Authors: Peter L Anderson; Jennifer J Kiser; Edward M Gardner; Joseph E Rower; Amie Meditz; Robert M Grant Journal: J Antimicrob Chemother Date: 2010-11-30 Impact factor: 5.790
Authors: Charlene A Flash; Valerie E Stone; Jennifer A Mitty; Matthew J Mimiaga; Kathryn T Hall; Douglas Krakower; Kenneth H Mayer Journal: AIDS Patient Care STDS Date: 2014-12 Impact factor: 5.078
Authors: Kristen Underhill; Don Operario; Matthew J Mimiaga; Margie R Skeer; Kenneth H Mayer Journal: Curr HIV/AIDS Rep Date: 2010-11 Impact factor: 5.071
Authors: Heather Senn; James Wilton; Malika Sharma; Shawn Fowler; Darrell H S Tan Journal: AIDS Res Hum Retroviruses Date: 2013-06-22 Impact factor: 2.205
Authors: Sarit A Golub; Kristi E Gamarel; H Jonathon Rendina; Anthony Surace; Corina L Lelutiu-Weinberger Journal: AIDS Patient Care STDS Date: 2013-04 Impact factor: 5.078
Authors: Martha A Abdulai; Frank Baiden; George Adjei; Samuel Afari-Asiedu; Kwame Adjei; Charlotte Tawiah; Sam Newton Journal: BMC Womens Health Date: 2012-11-01 Impact factor: 2.809