| Literature DB >> 20208534 |
Marc E Rothenberg1, Jonathan M Spergel, Joseph D Sherrill, Kiran Annaiah, Lisa J Martin, Antonella Cianferoni, Laura Gober, Cecilia Kim, Joseph Glessner, Edward Frackelton, Kelly Thomas, Carine Blanchard, Chris Liacouras, Ritu Verma, Seema Aceves, Margaret H Collins, Terri Brown-Whitehorn, Phil E Putnam, James P Franciosi, Rosetta M Chiavacci, Struan F A Grant, J Pablo Abonia, Patrick M A Sleiman, Hakon Hakonarson.
Abstract
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 x 10(-9)). TSLP is overexpressed in esophageal biopsies from individuals with EoE compared with unaffected individuals, whereas WDR36 expression is unaltered between the two groups. These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region.Entities:
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Year: 2010 PMID： 20208534 PMCID： PMC3740732 DOI： 10.1038/ng.547
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330