OBJECTIVE: To assess the association between in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and adverse birth outcomes. STUDY DESIGN: Retrospective cohort study involved IVF/ICSI patients who were treated in the Ottawa Fertility Centre from 1996 to 2005 with a viable pregnancy (>20 weeks of gestation) and mothers who conceived naturally. RESULTS: Eleven of the 1044 infants conceived with IVF/ICSI (1.1%) and 7 of the 1910 naturally conceived infants (0.4%) had congenital heart defects (P<0.01). Five of the 138 infants (3.6%) born to mothers with a body mass index>30 and conceived by IVF/ICSI had congenital heart defects, compared with none in the 240 infants born to mothers with a body mass index>30 and conceived naturally (P<0.01). CONCLUSION: Infants conceived with use of IVF/ICSI have three times as high a risk of a congenital heart defect as naturally conceived infants. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: To assess the association between in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and adverse birth outcomes. STUDY DESIGN: Retrospective cohort study involved IVF/ICSIpatients who were treated in the Ottawa Fertility Centre from 1996 to 2005 with a viable pregnancy (>20 weeks of gestation) and mothers who conceived naturally. RESULTS: Eleven of the 1044 infants conceived with IVF/ICSI (1.1%) and 7 of the 1910 naturally conceived infants (0.4%) had congenital heart defects (P<0.01). Five of the 138 infants (3.6%) born to mothers with a body mass index>30 and conceived by IVF/ICSI had congenital heart defects, compared with none in the 240 infants born to mothers with a body mass index>30 and conceived naturally (P<0.01). CONCLUSION:Infants conceived with use of IVF/ICSI have three times as high a risk of a congenital heart defect as naturally conceived infants. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Alexander N Yatsenko; Derek S O'Neil; Angshumoy Roy; Paola A Arias-Mendoza; Ruihong Chen; Lata J Murthy; Dolores J Lamb; Martin M Matzuk Journal: Mol Hum Reprod Date: 2011-09-12 Impact factor: 4.025
Authors: Angela L Schenewerk; Francisco Í Ramírez; Christopher Foote; Tieming Ji; Luis A Martínez-Lemus; Rocío Melissa Rivera Journal: Reproduction Date: 2013-11-20 Impact factor: 3.906
Authors: Emily W Harville; Gita D Mishra; Edwina Yeung; Sunni L Mumford; Enrique F Schisterman; Anne Marie Jukic; Elizabeth E Hatch; Ellen M Mikkelsen; Hong Jiang; Deborah B Ehrenthal; Christina A Porucznik; Joseph B Stanford; Shi-Wu Wen; Alysha Harvey; Danielle Symons Downs; Chittaranjan Yajnik; Donna Santillan; Mark Santillan; Thomas F McElrath; Jessica G Woo; Elaine M Urbina; Jorge E Chavarro; Daniela Sotres-Alvarez; Lydia Bazzano; Jun Zhang; Anne Steiner; Erica P Gunderson; Lauren A Wise Journal: Paediatr Perinat Epidemiol Date: 2019-10-28 Impact factor: 3.980