Jong In Han1, Heeseung Lee, Chi Hyo Kim, Guie Yong Lee. 1. Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea. hanji@ewha.ac.kr <hanji@ewha.ac.kr>
Abstract
STUDY OBJECTIVE: To determine if fentanyl-induced cough was dose-dependent in children and whether it could affect tracheal intubation. DESIGN: Prospective, randomized, double-blinded study. SETTING: Operating room of a university-affiliated hospital. PATIENTS: 160 ASA physical statusI pediatric patients, aged two to 14 years, scheduled for elective surgery during general anesthesia and requiring orotracheal intubation. INTERVENTIONS: Patients were divided into two groups. Group 1 patients were given fentanyl at a dosage of one microg/kg; Group 2 patients received two microg/kg of fentanyl. Induction of anesthesia was conducted immediately following cough cessation or one minute after the end of injection with propofol 2.5 mg/kg. At loss of eyelash reflex, rocuronium 0.6 mg/kg was given intravenously (IV). Two minutes later, tracheal intubation was started. MEASUREMENTS: Onset and degree of cough and intubating conditions were observed and recorded. MAIN RESULTS: No statistically significant differences in frequency of coughing or in intubating conditions between the two groups were noted. Cough severity in Group 1 was statistically lower than that of Group 2 (P < 0.05). Onset of cough in Group 2 (12.2 +/- 3.4 sec) was statistically shorter than in Group 1 (16.9 +/- 7.6 sec, P < 0.05). CONCLUSION:Fentanyl at doses of one and two microg/kg may induce coughing in pediatric patients.
RCT Entities:
STUDY OBJECTIVE: To determine if fentanyl-induced cough was dose-dependent in children and whether it could affect tracheal intubation. DESIGN: Prospective, randomized, double-blinded study. SETTING: Operating room of a university-affiliated hospital. PATIENTS: 160 ASA physical status I pediatric patients, aged two to 14 years, scheduled for elective surgery during general anesthesia and requiring orotracheal intubation. INTERVENTIONS:Patients were divided into two groups. Group 1 patients were given fentanyl at a dosage of one microg/kg; Group 2 patients received two microg/kg of fentanyl. Induction of anesthesia was conducted immediately following cough cessation or one minute after the end of injection with propofol 2.5 mg/kg. At loss of eyelash reflex, rocuronium 0.6 mg/kg was given intravenously (IV). Two minutes later, tracheal intubation was started. MEASUREMENTS: Onset and degree of cough and intubating conditions were observed and recorded. MAIN RESULTS: No statistically significant differences in frequency of coughing or in intubating conditions between the two groups were noted. Cough severity in Group 1 was statistically lower than that of Group 2 (P < 0.05). Onset of cough in Group 2 (12.2 +/- 3.4 sec) was statistically shorter than in Group 1 (16.9 +/- 7.6 sec, P < 0.05). CONCLUSION:Fentanyl at doses of one and two microg/kg may induce coughing in pediatric patients.
Authors: Rong Chen; Ling-Hua Tang; Tao Sun; Zi Zeng; Yun-Yan Zhang; Ke Ding; Qing-Tao Meng Journal: Front Pharmacol Date: 2020-10-28 Impact factor: 5.810