| Literature DB >> 20206644 |
Abid H Banday1, Bilal P Mir, Imtiyaz H Lone, K A Suri, H M Sampath Kumar.
Abstract
An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds 4b, 4c, 4e, 4f, 4h and 4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20206644 DOI： 10.1016/j.steroids.2010.02.014
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668