| Literature DB >> 20206440 |
Eri Kawata1, Eishi Ashihara, Yoko Nakagawa, Takahiro Kiuchi, Mai Ogura, Hisayuku Yao, Kazuki Sakai, Ruriko Tanaka, Rina Nagao, Asumi Yokota, Miki Takeuchi, Shinya Kimura, Hideyo Hirai, Taira Maekawa.
Abstract
Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell proliferation through the induction of apoptosis. Next, we investigated the effects of zoledronic acid (ZOL) on MM cells, and found that ZOL also induced apoptosis in MM cells. Furthermore, ZOL augmented the inhibitory effects of the PLK-1 siRNA. In conclusion, combining a PLK-1 siRNA with ZOL treatment is an attractive strategy against MM. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20206440 DOI： 10.1016/j.canlet.2010.02.008
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679