Synthesis of nanobioglass and formation of apatite rods to occlude exposed dentine tubules and eliminate hypersensitivity.

The occlusion of patent dentine tubules may reduce or eliminate hypersensitivity by restricting dentinal fluid movement. The efficacy of a novel sol-gel nanobioglass and a melt-derived bioglass to occlude tubules and promote apatite formation was tested by mechanically brushing a slurry of bioglass powder and human saliva onto dentine possessing exposed tubules. Scanning electron microscopy, focused ion beam and energy-dispersive X-ray spectroscopy were used to characterize the powders and assess tubule occlusion. Melt-derived bioglass possessed an irregular particle morphology and had a mean size of 3.30 +/- 0.42 microm. The sol-gel bioglass particles were spherical, with a mean size of 0.65 +/- 0.19 microm. Dentine treated with melt-derived bioglass exhibited a tightly adherent continuous apatite layer. Treatment with nanobioglass resulted in particle deposition within tubules and formation of apatite rods which were tightly adherent to tubule walls and continuous to a measured depth of 270 microm. 2010. Published by Elsevier Ltd.