Literature DB >> 20205635

Altered hyaluronan biosynthesis and cancer progression: an immunological perspective.

Laura Alaniz1, Mariana Garcia, Miguel Rizzo, Flavia Piccioni, Guillermo Mazzolini.   

Abstract

Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions, Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.

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Year:  2009        PMID： 20205635     DOI： 10.2174/138955709790361485

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  7 in total

1.  Glycosaminoglycan levels and structure in a mucopolysaccharidosis IIIA mice and the effect of a highly secreted sulfamidase engineered to cross the blood-brain barrier.

Authors:  F Maccari; N C Sorrentino; V Mantovani; F Galeotti; A Fraldi; N Volpi
Journal:  Metab Brain Dis       Date:  2016-09-01       Impact factor: 3.584

Review 2.  Viewing hyaluronan: imaging contributes to imagining new roles for this amazing matrix polymer.

Authors:  Carol A de la Motte; Judith A Drazba
Journal:  J Histochem Cytochem       Date:  2011-03       Impact factor: 2.479

3.  Correlation of hyaluronan deposition with infiltration of eosinophils and lymphocytes in a cockroach-induced murine model of asthma.

Authors:  Georgiana Cheng; Shadi Swaidani; Manisha Sharma; Mark E Lauer; Vincent C Hascall; Mark A Aronica
Journal:  Glycobiology       Date:  2012-08-23       Impact factor: 4.313

4.  Low molecular weight hyaluronan-pulsed human dendritic cells showed increased migration capacity and induced resistance to tumor chemoattraction.

Authors:  Manglio Rizzo; Juan Bayo; Flavia Piccioni; Mariana Malvicini; Esteban Fiore; Estanislao Peixoto; Mariana G García; Jorge B Aquino; Ariel Gonzalez Campaña; Gustavo Podestá; Marcelo Terres; Oscar Andriani; Laura Alaniz; Guillermo Mazzolini
Journal:  PLoS One       Date:  2014-09-19       Impact factor: 3.240

5.  4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.

Authors:  Hayato Nagase; Daisuke Kudo; Akiko Suto; Eri Yoshida; Shinichiro Suto; Mika Negishi; Ikuko Kakizaki; Kenichi Hakamada
Journal:  Pancreas       Date:  2017-02       Impact factor: 3.327

6.  Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity.

Authors:  Yeonsun Hong; Yoon Kyoung Kim; Gi Beom Kim; Gi-Hoon Nam; Seong A Kim; Yoon Park; Yoosoo Yang; In-San Kim
Journal:  J Extracell Vesicles       Date:  2019-09-28

7.  Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer.

Authors:  Ruocong Zhao; Yuanbin Cui; Yongfang Zheng; Shanglin Li; Jiang Lv; Qiting Wu; Youguo Long; Suna Wang; Yao Yao; Wei Wei; Jie Yang; Bin-Chao Wang; Zhenfeng Zhang; Hui Zeng; Yangqiu Li; Peng Li
Journal:  Front Immunol       Date:  2021-07-13       Impact factor: 7.561
  7 in total

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