Nan Luo1, Wai-Yee Ng, Puay-Ngoh Lau, Wing-Lok Au, Louis Cs Tan. 1. Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Block MD3, 16 Medical Drive, Singapore, 117597 Singapore. ephln@nus.edu.sg
Abstract
OBJECTIVE: The purpose of this study was to evaluate the responsiveness of the EQ-5D and the Parkinson's Disease Questionnaire (PDQ-8) to deterioration in health-related quality of life (HRQoL) in patients with Parkinson's disease (PD). METHODS: HRQoL and clinical data collected from 31 patients with PD (male: 74.2%, mean age: 61 years) who were surveyed with the EQ-5D and the PDQ-8 questionnaires in 2002 and 2006/2007 were analyzed. Responsiveness of the EQ-5D, PDQ-8, and Hoehn and Yahr (H&Y) staging were assessed according to Cohen's effect size (ES) and standardized response mean (SRM). RESULTS: The mean (standard deviation) EQ-5D index and PDQ-8 summary index (PDQ-8SI) scores were 0.76 (0.23) and 17.7 (14.2) at baseline and 0.52 (0.33) and 35.1 (17.4) at year four. Based on both ES and SRM indices, the rank order of responsiveness of the studied measures, from high to low, was PDQ-8SI (ES = 1.22), EQ-5D index score (ES = 1.06), H&Y score (ES = 0.82), and the EQ-VAS score (ES = 0.24). CONCLUSION: Both the EQ-5D and PDQ-8 are responsive to changes in health burden of the Parkinson's disease over a 4-year period.
OBJECTIVE: The purpose of this study was to evaluate the responsiveness of the EQ-5D and the Parkinson's Disease Questionnaire (PDQ-8) to deterioration in health-related quality of life (HRQoL) in patients with Parkinson's disease (PD). METHODS: HRQoL and clinical data collected from 31 patients with PD (male: 74.2%, mean age: 61 years) who were surveyed with the EQ-5D and the PDQ-8 questionnaires in 2002 and 2006/2007 were analyzed. Responsiveness of the EQ-5D, PDQ-8, and Hoehn and Yahr (H&Y) staging were assessed according to Cohen's effect size (ES) and standardized response mean (SRM). RESULTS: The mean (standard deviation) EQ-5D index and PDQ-8 summary index (PDQ-8SI) scores were 0.76 (0.23) and 17.7 (14.2) at baseline and 0.52 (0.33) and 35.1 (17.4) at year four. Based on both ES and SRM indices, the rank order of responsiveness of the studied measures, from high to low, was PDQ-8SI (ES = 1.22), EQ-5D index score (ES = 1.06), H&Y score (ES = 0.82), and the EQ-VAS score (ES = 0.24). CONCLUSION: Both the EQ-5D and PDQ-8 are responsive to changes in health burden of the Parkinson's disease over a 4-year period.
Authors: M Reuther; E A Spottke; J Klotsche; O Riedel; H Peter; K Berger; O Athen; R Köhne-Volland; R C Dodel Journal: Parkinsonism Relat Disord Date: 2006-10-19 Impact factor: 4.891
Authors: Edimansyah Abdin; Mythily Subramaniam; Janhavi Ajit Vaingankar; Nan Luo; Siow Ann Chong Journal: Qual Life Res Date: 2014-11-14 Impact factor: 4.147
Authors: Edimansyah Abdin; Mythily Subramaniam; Janhavi Ajit Vaingankar; Nan Luo; Siow Ann Chong Journal: Qual Life Res Date: 2013-04-03 Impact factor: 4.147
Authors: Miguel Ángel García-Gordillo; Borja del Pozo-Cruz; José Carmelo Adsuar; Fernando Ignacio Sánchez-Martínez; José María Abellán-Perpiñán Journal: Qual Life Res Date: 2013-11-22 Impact factor: 4.147
Authors: Gabriella Deli; István Balás; Tamás Dóczi; József Janszky; Kázmér Karádi; Zsuzsanna Aschermann; Ferenc Nagy; Attila Makkos; Márton Kovács; Edit Bosnyák; Norbert Kovács; Sámuel Komoly Journal: Parkinsons Dis Date: 2015-07-30
Authors: Herma Lennaerts; Marieke Groot; Maxime Steppe; Jenny T van der Steen; Marieke Van den Brand; Dorian van Amelsvoort; Kris Vissers; Marten Munneke; Bastiaan R Bloem Journal: BMC Palliat Care Date: 2017-11-25 Impact factor: 3.234