Literature DB >> 20204197

An efficient synthesis of (+/-)-frondosin B using a Stille-Heck reaction sequence.

Kye-Simeon Masters1, Bernard L Flynn.   

Abstract

A concise, convergent synthesis of (+/-)-frondosin B has been developed based on the application of a Stille-Heck reaction sequence of 2-chloro-5-methoxybenzo[b]furan-3-yl triflate and 2-(3-butenyl)-3-(trimethylstannyl)cyclohex-2-enone giving the racemic natural product in a 34% overall yield.

Entities:  

Mesh:

Substances:

Year:  2010        PMID: 20204197     DOI: 10.1039/b924542a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  1 in total

1.  Pd-catalyzed cross-coupling of α-(acyloxy)-tri-n-butylstannanes with alkenyl, aryl, and heteroaryl electrophiles.

Authors:  Mohan Goli; Anyu He; J R Falck
Journal:  Org Lett       Date:  2010-12-09       Impact factor: 6.005

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.