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Literature DB >> 20204195

A flexible asymmetric synthesis of the tetracyclic core of berkelic acid using a Horner-Wadsworth-Emmons/oxa-Michael cascade.

Abstract

The one-pot Horner-Wadsworth-Emmons/oxa-Michael cascade followed by spiroketalisation affords the tetracyclic benzannulated spiroketal core of berkelic acid, an extremophile natural product with selective activity against ovarian cancer.

Entities: Chemical Disease

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Substances：

Year: 2010 PMID： 20204195 DOI： 10.1039/b927219b

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

1 in total

1. A biosynthetically inspired synthesis of (-)-berkelic acid and analogs.

Authors: Christopher F Bender; Christopher L Paradise; Vincent M Lynch; Francis K Yoshimoto; Jef K De Brabander
Journal: Tetrahedron Date: 2018-01-12 Impact factor: 2.457

1 in total