Taruna Likhari1, Rousseau Gama. 1. Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, West Midlands WV10 0QP, UK. t.likhari@btinternet.com
Abstract
OBJECTIVE: To determine whether ethnic differences exist in glycated haemoglobin between white subjects and those of South Asian origin with normal glucose tolerance (NGT) METHODS: Erythrocyte glycated haemoglobin (HbA(1c)) was compared between white subjects and those of South Asian origin with NGT defined by a 75 g oral glucose tolerance test (OGTT). RESULTS: 139 subjects with NGT comprising 36 people of South Asian origin (20 female) and 103 white subjects (49 female) were compared. Subjects of South Asian origin were younger (p<0.001) and weighed less (p<0.001) than white subjects. Fasting and 2 h capillary plasma glucose concentrations were similar in subjects of South Asian origin and white subjects, but HbA(1c) levels were higher (p<0.05) in subjects of South Asian origin (6.11+/-0.58%) compared with levels in white subjects (5.90+/-0.40%). CONCLUSION: In subjects with similar fasting and postprandial glycaemia on OGTT, those of South Asian origin have higher HbA(1c) levels than white subjects. It is speculated that the higher glycaemia-independent HBA(1c) levels in people of South Asian origin could possibly contribute to their increase cardiovascular risk.
OBJECTIVE: To determine whether ethnic differences exist in glycated haemoglobin between white subjects and those of South Asian origin with normal glucose tolerance (NGT) METHODS: Erythrocyte glycated haemoglobin (HbA(1c)) was compared between white subjects and those of South Asian origin with NGT defined by a 75 g oral glucose tolerance test (OGTT). RESULTS: 139 subjects with NGT comprising 36 people of South Asian origin (20 female) and 103 white subjects (49 female) were compared. Subjects of South Asian origin were younger (p<0.001) and weighed less (p<0.001) than white subjects. Fasting and 2 h capillary plasma glucose concentrations were similar in subjects of South Asian origin and white subjects, but HbA(1c) levels were higher (p<0.05) in subjects of South Asian origin (6.11+/-0.58%) compared with levels in white subjects (5.90+/-0.40%). CONCLUSION: In subjects with similar fasting and postprandial glycaemia on OGTT, those of South Asian origin have higher HbA(1c) levels than white subjects. It is speculated that the higher glycaemia-independent HBA(1c) levels in people of South Asian origin could possibly contribute to their increase cardiovascular risk.
Authors: Sophie V Eastwood; Therese Tillin; Naveed Sattar; Nita G Forouhi; Alun D Hughes; Nish Chaturvedi Journal: Diabetes Care Date: 2015-10-20 Impact factor: 19.112
Authors: Elizabeth Selvin; Andreea M Rawlings; Richard M Bergenstal; Josef Coresh; Frederick L Brancati Journal: Diabetes Care Date: 2013-05-30 Impact factor: 19.112
Authors: S V Eastwood; T Tillin; J Mayet; D K Shibata; A Wright; J Heasman; N Beauchamp; N G Forouhi; A D Hughes; N Chaturvedi Journal: Diabet Med Date: 2015-10-19 Impact factor: 4.359