| Literature DB >> 20202843 |
Kevin K-C Liu1, Bruce A Lefker, Mark A Dombroski, Phoebe Chiang, Peter Cornelius, Terrell A Patterson, Yuan Zeng, Stephanie Santucci, Elizabeth Tomlinson, Colleen P Gibbons, Ravi Marala, Janice A Brown, Jimmy X Kong, Eunsun Lee, Wendy Werner, Zane Wenzel, Craig Giragossian, Hou Chen, Steven B Coffey.
Abstract
Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor. After medicinal chemistry optimization and SAR studies, orally active proline amides with robust efficacy in a rodent food intake inhibition model were uncovered. 2010. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID： 20202843 DOI： 10.1016/j.bmcl.2010.01.107
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823