OBJECTIVES: This study sought to examine the prevalence and predictors of pulmonary regurgitation (PR) following balloon dilation (BD) for pulmonary stenosis (PS) and to investigate its impact on ventricular volume and function, and exercise tolerance. BACKGROUND: Balloon pulmonary valvuloplasty relieves PS but can cause late PR. The sequelae of isolated PR are not well understood. METHODS: Patients were at least 7 years of age and 5 years removed from BD, and had no other form of congenital heart disease or significant residual PS. Cardiac magnetic resonance imaging and exercise testing were performed prospectively to quantify PR fraction, ventricular volumes and function, and exercise capacity. RESULTS: Forty-one patients underwent testing a median of 13.1 years after BD. The median PR fraction was 10%; 14 patients (34%) had PR fraction >15%; 7 (17%) had PR >30%. PR fraction was associated with age at dilation (ln-transformed, R = -0.47, p = 0.002) and balloon:annulus ratio (R = 0.57, p < 0.001). The mean right ventricular (RV) end-diastolic volume z-score was 1.8 +/- 1.9; RV dilation (z-score > or =2) was present in 14/35 patients (40%). PR fraction correlated closely with indexed RV end-diastolic volume (R = 0.79, p < 0.001) and modestly with RV ejection fraction (R = 0.50, p < 0.001). Overall, peak oxygen consumption (Vo(2)) (% predicted) was below average (92 +/- 17%, p = 0.006). Patients with PR fraction >15% had significantly lower peak Vo(2) than those with less PR (85 +/- 17% vs. 96 +/- 16%, p = 0.03). CONCLUSIONS: Mild PR and RV dilation are common in the long term following BD. A PR fraction >15% is associated with lower peak Vo(2), suggesting that isolated PR and consequent RV dilation are related to impaired exercise cardiopulmonary function. Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
OBJECTIVES: This study sought to examine the prevalence and predictors of pulmonary regurgitation (PR) following balloon dilation (BD) for pulmonary stenosis (PS) and to investigate its impact on ventricular volume and function, and exercise tolerance. BACKGROUND:Balloon pulmonary valvuloplasty relieves PS but can cause late PR. The sequelae of isolated PR are not well understood. METHODS:Patients were at least 7 years of age and 5 years removed from BD, and had no other form of congenital heart disease or significant residual PS. Cardiac magnetic resonance imaging and exercise testing were performed prospectively to quantify PR fraction, ventricular volumes and function, and exercise capacity. RESULTS: Forty-one patients underwent testing a median of 13.1 years after BD. The median PR fraction was 10%; 14 patients (34%) had PR fraction >15%; 7 (17%) had PR >30%. PR fraction was associated with age at dilation (ln-transformed, R = -0.47, p = 0.002) and balloon:annulus ratio (R = 0.57, p < 0.001). The mean right ventricular (RV) end-diastolic volume z-score was 1.8 +/- 1.9; RV dilation (z-score > or =2) was present in 14/35 patients (40%). PR fraction correlated closely with indexed RV end-diastolic volume (R = 0.79, p < 0.001) and modestly with RV ejection fraction (R = 0.50, p < 0.001). Overall, peak oxygen consumption (Vo(2)) (% predicted) was below average (92 +/- 17%, p = 0.006). Patients with PR fraction >15% had significantly lower peak Vo(2) than those with less PR (85 +/- 17% vs. 96 +/- 16%, p = 0.03). CONCLUSIONS: Mild PR and RV dilation are common in the long term following BD. A PR fraction >15% is associated with lower peak Vo(2), suggesting that isolated PR and consequent RV dilation are related to impaired exercise cardiopulmonary function. Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Authors: Mohamed Eid Fawzy; Walid Hassan; Bahaa M Fadel; Hani Sergani; Fayez El Shaer; Hassan El Widaa; Aly Al Sanei Journal: Am Heart J Date: 2007-03 Impact factor: 4.749
Authors: Olivier Ghez; Victor T Tsang; Alessandra Frigiola; Louise Coats; Andrew Taylor; Carin Van Doorn; Philip Bonhoeffer; Marc De Leval Journal: Eur J Cardiothorac Surg Date: 2007-01-30 Impact factor: 4.191
Authors: Jeffery Meadows; Andrew J Powell; Tal Geva; Adam Dorfman; Kim Gauvreau; Jonathan Rhodes Journal: Am J Cardiol Date: 2007-08-21 Impact factor: 2.778
Authors: Philipp Lurz; Johannes Nordmeyer; Vivek Muthurangu; Sachin Khambadkone; Graham Derrick; Robert Yates; Michael Sury; Philipp Bonhoeffer; Andrew M Taylor Journal: Circulation Date: 2009-06-01 Impact factor: 29.690
Authors: Rachel M Wald; Idith Haber; Ron Wald; Anne Marie Valente; Andrew J Powell; Tal Geva Journal: Circulation Date: 2009-03-02 Impact factor: 29.690
Authors: Nicole J Sutton; Lynn Peng; James E Lock; Peter Lang; Gerald R Marx; Tracy J Curran; Julie-Ann O'Neill; Sarah T Picard; Jonathan Rhodes Journal: Am Heart J Date: 2007-10-17 Impact factor: 4.749
Authors: Laura Mercer-Rosa; Eitan Ingall; Xuemei Zhang; Michael McBride; Stephen Kawut; Mark Fogel; Stephen Paridon; Elizabeth Goldmuntz Journal: Pediatr Cardiol Date: 2014-12-18 Impact factor: 1.655
Authors: Christina Ronai; Rahul H Rathod; Audrey C Marshall; Rebecca Oduor; Kimberlee Gauvreau; Steven D Colan; David W Brown Journal: Pediatr Cardiol Date: 2015-03-13 Impact factor: 1.655
Authors: Victor Bautista-Hernandez; Ivonne Cardenas; Isaac Martinez-Bendayan; Hugo Loyola; Fernando Rueda; Francisco Portela Journal: Pediatr Cardiol Date: 2012-11-21 Impact factor: 1.655