Literature DB >> 20201017

Pyroptosis - a cell death modality of its kind?

Oliver Kepp1, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer.   

Abstract

The term "pyroptosis" was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis - which can also be triggered by non-bacterial pathological stimuli - truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.

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Year:  2010        PMID: 20201017     DOI: 10.1002/eji.200940160

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN: 0014-2980            Impact factor:   5.532


  54 in total

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