Literature DB >> 20201016

NOD-like receptor (NLR) signaling beyond the inflammasome.

Patrick J Shaw1, Mohamed Lamkanfi, Thirumala-Devi Kanneganti.   

Abstract

Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.

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Year:  2010        PMID： 20201016      PMCID： PMC3001129          DOI： 10.1002/eji.200940211

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


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