Literature DB >> 20201013

Inflammasomes as microbial sensors.

Luigi Franchi1, Raul Muñoz-Planillo, Thornik Reimer, Tatjana Eigenbrod, Gabriel Núñez.   

Abstract

Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.

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Year:  2010        PMID： 20201013     DOI： 10.1002/eji.200940180

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  60 in total

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Review 3.  Sterile inflammatory responses mediated by the NLRP3 inflammasome.

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Review 4.  Sensing damage by the NLRP3 inflammasome.

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5.  Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein.

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6.  TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.

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7.  A Role for the Inflammasome in Spontaneous Labor at Term.

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Journal:  Am J Reprod Immunol       Date:  2016-03-08       Impact factor: 3.886

8.  In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.

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Review 9.  The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis?

Authors:  J Michelle Kahlenberg; Mariana J Kaplan
Journal:  Curr Opin Rheumatol       Date:  2014-09       Impact factor: 5.006

10.  Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.

Authors:  Mizuho Hasegawa; Nobuhiko Kamada; Yizu Jiao; Meng Zhen Liu; Gabriel Núñez; Naohiro Inohara
Journal:  J Immunol       Date:  2012-08-10       Impact factor: 5.422
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