OBJECTIVE: Perfluorooctanoate (PFOA) has been associated with impaired lactation in mice. We examined whether maternal perfluorooctanesulfonate (PFOS) and PFOA concentrations correlated with duration of breastfeeding among women. METHODS: We randomly selected 1400 pregnant women from the Danish national birth cohort (1996-2002) and measured PFOS and PFOA concentrations in early pregnancy by using high performance liquid chromatography/tandem mass spectrometry. Self-reported data on the duration of any and exclusive breastfeeding were collected twice during telephone interviews around 6 and 18 months after the birth of the child. RESULTS: The duration of breastfeeding decreased with increasing concentrations of pregnancy PFOS and PFOA among multiparous women, for whom the adjusted odds ratios (OR) for weaning before 6 months of age were 1.20 (95% CI 1.06-1.37) per 10 ng/ml increase in PFOS concentrations and 1.23 (95% CI 1.13-1.33) per 1 ng/ml increase in PFOA concentrations. No consistent association was found for primiparous women. CONCLUSIONS: These findings suggest that PFOA and PFOS may reduce the ability to lactate, but could equally reflect reverse causation since no association was seen in primiparous women.
OBJECTIVE:Perfluorooctanoate (PFOA) has been associated with impaired lactation in mice. We examined whether maternal perfluorooctanesulfonate (PFOS) and PFOA concentrations correlated with duration of breastfeeding among women. METHODS: We randomly selected 1400 pregnant women from the Danish national birth cohort (1996-2002) and measured PFOS and PFOA concentrations in early pregnancy by using high performance liquid chromatography/tandem mass spectrometry. Self-reported data on the duration of any and exclusive breastfeeding were collected twice during telephone interviews around 6 and 18 months after the birth of the child. RESULTS: The duration of breastfeeding decreased with increasing concentrations of pregnancy PFOS and PFOA among multiparous women, for whom the adjusted odds ratios (OR) for weaning before 6 months of age were 1.20 (95% CI 1.06-1.37) per 10 ng/ml increase in PFOS concentrations and 1.23 (95% CI 1.13-1.33) per 1 ng/ml increase in PFOA concentrations. No consistent association was found for primiparous women. CONCLUSIONS: These findings suggest that PFOA and PFOS may reduce the ability to lactate, but could equally reflect reverse causation since no association was seen in primiparous women.
Authors: Samantha L Kingsley; Melissa N Eliot; Karl T Kelsey; Antonia M Calafat; Shelley Ehrlich; Bruce P Lanphear; Aimin Chen; Joseph M Braun Journal: Environ Res Date: 2018-05-07 Impact factor: 6.498
Authors: Anne P Starling; John L Adgate; Richard F Hamman; Katerina Kechris; Antonia M Calafat; Dana Dabelea Journal: Environ Int Date: 2019-07-05 Impact factor: 9.621
Authors: A L Brantsæter; K W Whitworth; T A Ydersbond; L S Haug; M Haugen; H K Knutsen; C Thomsen; H M Meltzer; G Becher; A Sabaredzovic; J A Hoppin; M Eggesbø; M P Longnecker Journal: Environ Int Date: 2013-02-15 Impact factor: 9.621
Authors: Megan E Romano; Yingying Xu; Antonia M Calafat; Kimberly Yolton; Aimin Chen; Glenys M Webster; Melissa N Eliot; Cynthia R Howard; Bruce P Lanphear; Joseph M Braun Journal: Environ Res Date: 2016-05-11 Impact factor: 6.498
Authors: Natalie M Crawford; Suzanne E Fenton; Mark Strynar; Erin P Hines; David A Pritchard; Anne Z Steiner Journal: Reprod Toxicol Date: 2017-01-19 Impact factor: 3.143
Authors: Joshua P Mogus; Charlotte D LaPlante; Ruby Bansal; Klara Matouskova; Benjamin R Schneider; Elizabeth Daniele; Shannon J Silva; Mary J Hagen; Karen A Dunphy; D Joseph Jerry; Sallie S Schneider; Laura N Vandenberg Journal: Endocrinology Date: 2021-06-01 Impact factor: 4.736