Ali Borazan1, Dogan Nasir Binici. 1. Mustafa Kemal University, Department of Nephrology, Hatay, Turkey. borazanali@hotmail.com
Abstract
OBJECTIVE: The prevalence and risk factors of cardiovascular disease (CVD) are increasing in end stage renal disease (ESRD) patients. In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis. MATERIALS AND METHODS: 64 HOMA-IR-positive and 114 HOMA-IR-negative patients were enrolled in this study. Blood samples were obtained from the patients for fasting plasma glucose, insulin, CRP, fibrinogen, uric acid, total homocysteine, urea, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, total protein, and albumin analysis after physical examinations and anamnesis were completed. RESULTS: Fibrinogen and CRP levels of HOMA-IR-positive HD patients were significantly increased compared to non-insulin resistants. Furthermore, there is significant positive relationship between insulin resistance and serum CRP and fibrinogen levels in these HOMA-IR-positive HD patients (r = 0.258, p < 0.001). CONCLUSION: We found out that the fibrinogen and CRP levels are significantly high in HOMA-IR positive HD patients, according to determine the risk ratio for coronary artery disease in HD patients, and think that an assessment of insulin resistance is necessary.
OBJECTIVE: The prevalence and risk factors of cardiovascular disease (CVD) are increasing in end stage renal disease (ESRD) patients. In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis. MATERIALS AND METHODS: 64 HOMA-IR-positive and 114 HOMA-IR-negative patients were enrolled in this study. Blood samples were obtained from the patients for fasting plasma glucose, insulin, CRP, fibrinogen, uric acid, total homocysteine, urea, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, total protein, and albumin analysis after physical examinations and anamnesis were completed. RESULTS:Fibrinogen and CRP levels of HOMA-IR-positive HDpatients were significantly increased compared to non-insulin resistants. Furthermore, there is significant positive relationship between insulin resistance and serum CRP and fibrinogen levels in these HOMA-IR-positive HDpatients (r = 0.258, p < 0.001). CONCLUSION: We found out that the fibrinogen and CRP levels are significantly high in HOMA-IR positive HDpatients, according to determine the risk ratio for coronary artery disease in HDpatients, and think that an assessment of insulin resistance is necessary.
Authors: Adriana M Hung; Mary B Sundell; Natalia E Plotnikova; Aihua Bian; Ayumi Shintani; Charles D Ellis; Edward D Siew; T Alp Ikizler Journal: J Ren Nutr Date: 2012-09-07 Impact factor: 3.655
Authors: Kinga Giers; Stanisław Niemczyk; Katarzyna Szamotulska; Katarzyna Romejko-Ciepielewska; Ewa Paklerska; Zbigniew Bartoszewicz; Ryszard Pacho; Mariusz Jasik; Joanna Matuszkiewicz-Rowińska Journal: Med Sci Monit Date: 2015-02-20