OBJECTIVES: Atrial fibrillation (AF) is one of the most frequent heart rhythm disorders. It potentially influences cardiac function and its measurement. Cardiac magnetic resonance imaging (CMR) has become the new gold standard for non-invasive assessment of cardiac output (CO). A novel inert gas rebreathing (IGR) device based on the Fick Principle also proved promising in patients in sinus rhythm (SR). The aim of our study was to compare the agreement of non-invasive CO measurements between CMR and IGR in AF patients. METHODS: A total of 68 patients, 34 with AF and 34 pair-matched controls in SR, were included. RESULTS: Bland-Altman analysis showed good agreement between both methods, with an average deviation of 0.2 +/-1.2 l/min in the AF group versus 0.3 +/-1.0 l/min in the SR group (p = 0.77). IGR demonstrated good agreement for CO between 2.0 and 5.4 l/min. However, in hyperdynamic circulatory conditions (CO >5.5 l/min), the increasing disagreement of IGR and CMR measurements reached statistical significance. CONCLUSIONS: Non-invasive CO measurements using CMR and IGR are feasible in patients suffering from AF. Good agreement was found between the two methods in an unselected cohort. Hyperdynamic circulatory conditions can lead to significant measurement differences which, however, do not affect the reproducibility of IGR.
OBJECTIVES:Atrial fibrillation (AF) is one of the most frequent heart rhythm disorders. It potentially influences cardiac function and its measurement. Cardiac magnetic resonance imaging (CMR) has become the new gold standard for non-invasive assessment of cardiac output (CO). A novel inert gas rebreathing (IGR) device based on the Fick Principle also proved promising in patients in sinus rhythm (SR). The aim of our study was to compare the agreement of non-invasive CO measurements between CMR and IGR in AFpatients. METHODS: A total of 68 patients, 34 with AF and 34 pair-matched controls in SR, were included. RESULTS: Bland-Altman analysis showed good agreement between both methods, with an average deviation of 0.2 +/-1.2 l/min in the AF group versus 0.3 +/-1.0 l/min in the SR group (p = 0.77). IGR demonstrated good agreement for CO between 2.0 and 5.4 l/min. However, in hyperdynamic circulatory conditions (CO >5.5 l/min), the increasing disagreement of IGR and CMR measurements reached statistical significance. CONCLUSIONS: Non-invasive CO measurements using CMR and IGR are feasible in patients suffering from AF. Good agreement was found between the two methods in an unselected cohort. Hyperdynamic circulatory conditions can lead to significant measurement differences which, however, do not affect the reproducibility of IGR.
Authors: Frederik Trinkmann; Manuel Berger; Ursula Hoffmann; Martin Borggrefe; Jens J Kaden; Joachim Saur Journal: Clin Res Cardiol Date: 2011-07-01 Impact factor: 5.460
Authors: Frederik Trinkmann; Manuel Berger; Christina Doesch; Theano Papavassiliu; Stefan O Schoenberg; Martin Borggrefe; Jens J Kaden; Joachim Saur Journal: J Clin Monit Comput Date: 2015-06-27 Impact factor: 2.502
Authors: Ksenija Stach; Julia D Michels; Christina Doesch; Joachim Brade; Theano Papavassiliu; Martin Borggrefe; Ibrahim Akin; Joachim Saur; Frederik Trinkmann Journal: Biomed Rep Date: 2019-07-18
Authors: Joachim Saur; Frederik Trinkmann; Christina Doesch; Armin Scherhag; Joachim Brade; Stefan O Schoenberg; Martin Borggrefe; Jens J Kaden; Theano Papavassiliu Journal: Lung Date: 2010-07-31 Impact factor: 2.584