Literature DB >> 20197050

New uses for old drugs: neonatal diabetes and sulphonylureas.

Frances M Ashcroft1.   

Abstract

The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20197050     DOI： 10.1016/j.cmet.2010.02.004

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  22 in total

Review 1.  The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.

Authors:  James S McTaggart; Rebecca H Clark; Frances M Ashcroft
Journal:  J Physiol       Date:  2010-06-02       Impact factor: 5.182

Review 2.  The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.

Authors:  Sujay V Kharade; Colin Nichols; Jerod S Denton
Journal:  Future Med Chem       Date:  2016-05-10       Impact factor: 3.808

Review 3.  Ion Channels of the Islets in Type 2 Diabetes.

Authors:  David A Jacobson; Show-Ling Shyng
Journal:  J Mol Biol       Date:  2019-08-30       Impact factor: 5.469

Review 4.  Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.

Authors:  Yi Quan; Andrew Barszczyk; Zhong-ping Feng; Hong-shuo Sun
Journal:  Acta Pharmacol Sin       Date:  2011-05-23       Impact factor: 6.150

Review 5.  Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.

Authors:  S Seino
Journal:  Diabetologia       Date:  2012-05-04       Impact factor: 10.122

6.  A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.

Authors:  Roope Männikkö; Phillip J Stansfeld; Alexandra S Ashcroft; Andrew T Hattersley; Mark S P Sansom; Sian Ellard; Frances M Ashcroft
Journal:  J Physiol       Date:  2011-05-03       Impact factor: 5.182

7.  Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls.

Authors:  D Carmody; A N Pastore; K A Landmeier; L R Letourneau; R Martin; J L Hwang; R N Naylor; S J Hunter; M E Msall; L H Philipson; M N Scott; S A W Greeley
Journal:  Diabet Med       Date:  2016-06-22       Impact factor: 4.359

Review 8.  K(ATP) channels and islet hormone secretion: new insights and controversies.

Authors:  Frances M Ashcroft; Patrik Rorsman
Journal:  Nat Rev Endocrinol       Date:  2013-09-17       Impact factor: 43.330

9.  The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes.

Authors:  Veronica Lang; Peter E Light
Journal:  Pharmgenomics Pers Med       Date:  2010-11-24

10.  Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse.

Authors:  S Zertal-Zidani; K Busiah; A Edelman; M Polak; R Scharfmann
Journal:  Diabetologia       Date:  2012-11-24       Impact factor: 10.122
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