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Literature DB >> 20197033

On the role of acylation of transmembrane proteins.

Abstract

Acylation is a frequent means to ensure membrane association of a variety of soluble proteins in living cells. However, many transmembrane proteins are palmitoylated, indicating that this posttranslational modification may also serve as a means to regulate protein trafficking. Based on coarse-grained membrane simulations, we find that protein acylation significantly alters the tilting of transmembrane proteins with respect to the bilayer normal. In addition, the proteins' partitioning behavior and cluster formation ability due to hydrophobic mismatching is strongly altered. Based on our results, we propose that acylation is a potent means to regulate the trafficking of transmembrane proteins along the early secretory pathway. 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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Year: 2010 PMID： 20197033 PMCID： PMC2830467 DOI： 10.1016/j.bpj.2009.11.014

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

21 in total

1. Dynamics of domain growth in self-assembled fluid vesicles.

Authors: Mohamed Laradji; P B Sunil Kumar
Journal: Phys Rev Lett Date: 2004-11-04 Impact factor: 9.161

2. An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.

Authors: Oliver Rocks; Anna Peyker; Martin Kahms; Peter J Verveer; Carolin Koerner; Maria Lumbierres; Jürgen Kuhlmann; Herbert Waldmann; Alfred Wittinghofer; Philippe I H Bastiaens
Journal: Science Date: 2005-02-10 Impact factor: 47.728

3. Constant-pressure and constant-surface tension simulations in dissipative particle dynamics.

Authors: Ask F Jakobsen
Journal: J Chem Phys Date: 2005-03-22 Impact factor: 3.488

4. Kin recognition. A model for the retention of Golgi enzymes.

Authors: T Nilsson; P Slusarewicz; M H Hoe; G Warren
Journal: FEBS Lett Date: 1993-09-06 Impact factor: 4.124

Review 5. Lipids do influence protein function-the hydrophobic matching hypothesis revisited.

Authors: Morten Ø Jensen; Ole G Mouritsen
Journal: Biochim Biophys Acta Date: 2004-11-03

6. Mattress model of lipid-protein interactions in membranes.

Authors: O G Mouritsen; M Bloom
Journal: Biophys J Date: 1984-08 Impact factor: 4.033

7. The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.

Authors: Jacqueline Stöckli; Jack Rohrer
Journal: Mol Biol Cell Date: 2004-03-19 Impact factor: 4.138

8. Secretory cargo regulates the turnover of COPII subunits at single ER exit sites.

Authors: Rebecca Forster; Matthias Weiss; Timo Zimmermann; Emmanuel G Reynaud; Fatima Verissimo; David J Stephens; Rainer Pepperkok
Journal: Curr Biol Date: 2006-01-24 Impact factor: 10.834

9. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.

Authors: J Shawn Goodwin; Kimberly R Drake; Carl Rogers; Latasha Wright; Jennifer Lippincott-Schwartz; Mark R Philips; Anne K Kenworthy
Journal: J Cell Biol Date: 2005-07-18 Impact factor: 10.539

10. An investigation of the role of transmembrane domains in Golgi protein retention.

Authors: S Munro
Journal: EMBO J Date: 1995-10-02 Impact factor: 11.598

7 in total

1. Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes.

Authors: Bjoern E S Olausson; Alan Grossfield; Michael C Pitman; Michael F Brown; Scott E Feller; Alexander Vogel
Journal: J Am Chem Soc Date: 2012-02-22 Impact factor: 15.419

On the role of acylation of transmembrane proteins.

1. Dynamics of domain growth in self-assembled fluid vesicles.

2. An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.

3. Constant-pressure and constant-surface tension simulations in dissipative particle dynamics.

4. Kin recognition. A model for the retention of Golgi enzymes.

Review 5. Lipids do influence protein function-the hydrophobic matching hypothesis revisited.

6. Mattress model of lipid-protein interactions in membranes.

7. The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.

8. Secretory cargo regulates the turnover of COPII subunits at single ER exit sites.

9. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.

10. An investigation of the role of transmembrane domains in Golgi protein retention.

1. Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes.

Review 2. Protein sorting and membrane-mediated interactions.

3. Aggregation of model membrane proteins, modulated by hydrophobic mismatch, membrane curvature, and protein class.

Review 4. Regulation of Dynamic Protein S-Acylation.

5. The role of shape complementarity in the protein-protein interactions.

Review 6. Insights into auto-S-fatty acylation: targets, druggability, and inhibitors.

7. Formation of raft-like assemblies within clusters of influenza hemagglutinin observed by MD simulations.