Literature DB >> 20195016

Magnification of photonic crystal fluorescence enhancement via TM resonance excitation and TE resonance extraction on a dielectric nanorod surface.

Hsin-Yu Wu1, Wei Zhang, Patrick C Mathias, Brian T Cunningham.   

Abstract

Using a one-dimensional grating surface photonic crystal (PC), we experimentally demonstrate that the detection of fluorescent molecules on a PC surface can be substantially magnified through the combined effects of resonance-enhanced excitation of the fluorescent dye, resonance-enhanced extraction of the fluorescence emission and a dielectric nanorod surface coating increasing the surface area available for fluorophore-PC interaction. Enhanced excitation is obtained by engineering a high-Q TM resonant mode to efficiently couple with an incident TM-polarized lambda = 633 nm laser for exciting Cyanine-5 (Cy5). Enhanced extraction results from a low-Q TE resonance designed to spectrally overlap the Cy5 emission spectrum for channeling TE-polarized emission towards the detection instrument. The entire PC surface is coated with a porous film of TiO(2) nanorods that allows more fluorophores to penetrate into the region of enhanced near-electric fields. Experimental results reveal a 588-fold enhancement in fluorescence intensity relative to an unpatterned glass surface.

Entities:  

Year:  2010        PMID: 20195016     DOI: 10.1088/0957-4484/21/12/125203

Source DB:  PubMed          Journal:  Nanotechnology        ISSN: 0957-4484            Impact factor:   3.874


  8 in total

1.  Photobleaching on photonic crystal enhanced fluorescence surfaces.

Authors:  Vikram Chaudhery; Meng Lu; Cheng Sheng Huang; Sherine George; Brian T Cunningham
Journal:  J Fluoresc       Date:  2010-11-12       Impact factor: 2.217

Review 2.  Photonic crystal enhanced fluorescence for early breast cancer biomarker detection.

Authors:  Brian T Cunningham; Richard C Zangar
Journal:  J Biophotonics       Date:  2012-06-27       Impact factor: 3.207

3.  Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review.

Authors:  B T Cunningham; M Zhang; Y Zhuo; L Kwon; C Race
Journal:  IEEE Sens J       Date:  2015-05-05       Impact factor: 3.301

4.  Application of photonic crystal enhanced fluorescence to cancer biomarker microarrays.

Authors:  Cheng-Sheng Huang; Sherine George; Meng Lu; Vikram Chaudhery; Ruimin Tan; Richard C Zangar; Brian T Cunningham
Journal:  Anal Chem       Date:  2011-01-21       Impact factor: 6.986

5.  Application of photonic crystal enhanced fluorescence to detection of low serum concentrations of human IgE antibodies specific for a purified cat allergen (Fel D1).

Authors:  Yafang Tan; John F Halsey; Tiantian Tang; Scott Vande Wetering; Elaine Taine; Mark Van Cleve; Brian T Cunningham
Journal:  Biosens Bioelectron       Date:  2015-09-14       Impact factor: 10.618

6.  Photonic crystal enhancement of a homogeneous fluorescent assay using submicron fluid channels fabricated by E-jet patterning.

Authors:  Yafang Tan; Erick Sutanto; Andrew G Alleyne; Brian T Cunningham
Journal:  J Biophotonics       Date:  2013-12-23       Impact factor: 3.207

7.  Spatially selective photonic crystal enhanced fluorescence and application to background reduction for biomolecule detection assays.

Authors:  Vikram Chaudhery; Cheng-Sheng Huang; Anusha Pokhriyal; James Polans; Brian T Cunningham
Journal:  Opt Express       Date:  2011-11-07       Impact factor: 3.894

Review 8.  Label-Free Biosensor Imaging on Photonic Crystal Surfaces.

Authors:  Yue Zhuo; Brian T Cunningham
Journal:  Sensors (Basel)       Date:  2015-08-28       Impact factor: 3.576

  8 in total

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