OBJECTIVE: To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < or = albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbuminuria (ACR > or = 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14 (7.1%) diabetic youth with an elevated ACR (> or =30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% confidence interval: 11.1-22.6) higher in the diabetic than in the nondiabetic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely transient in nondiabetic youth, but it is relatively frequent and largely persistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria.
OBJECTIVE: To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < or = albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbuminuria (ACR > or = 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14 (7.1%) diabetic youth with an elevated ACR (> or =30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% confidence interval: 11.1-22.6) higher in the diabetic than in the nondiabetic youth. CONCLUSIONS:Elevated albuminuria is infrequent and largely transient in nondiabetic youth, but it is relatively frequent and largely persistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria.
Authors: Maike C Eppens; Maria E Craig; Janine Cusumano; Stephen Hing; Albert K F Chan; Neville J Howard; Martin Silink; Kim C Donaghue Journal: Diabetes Care Date: 2006-06 Impact factor: 19.112
Authors: Meda E Pavkov; Peter H Bennett; William C Knowler; Jonathan Krakoff; Maurice L Sievers; Robert G Nelson Journal: JAMA Date: 2006-07-26 Impact factor: 56.272
Authors: Marianne McPherson Yee; Shameem F Jabbar; Ifeyinwa Osunkwo; Lisa Clement; Peter A Lane; James R Eckman; Antonio Guasch Journal: Clin J Am Soc Nephrol Date: 2011-09-22 Impact factor: 8.237
Authors: Nora Franceschini; Nawar M Shara; Hong Wang; V Saroja Voruganti; Sandy Laston; Karin Haack; Elisa T Lee; Lyle G Best; Jean W Maccluer; Barbara J Cochran; Thomas D Dyer; Barbara V Howard; Shelley A Cole; Kari E North; Jason G Umans Journal: Kidney Int Date: 2012-04-18 Impact factor: 10.612
Authors: Allison B Dart; Elizabeth A Sellers; Patricia J Martens; Claudio Rigatto; Marni D Brownell; Heather J Dean Journal: Diabetes Care Date: 2012-03-19 Impact factor: 19.112
Authors: Anna R Kahkoska; Scott Isom; Jasmin Divers; Elizabeth J Mayer-Davis; Lawrence Dolan; Amy S Shah; Maryam Afkarian; David J Pettitt; Jean M Lawrence; Santica Marcovina; Sharon H Saydah; Dana Dabelea; David M Maahs; Amy K Mottl Journal: J Diabetes Complications Date: 2018-10-04 Impact factor: 3.219
Authors: Mohammad Haghighatpanah; Amir Sasan Mozaffari Nejad; Maryam Haghighatpanah; Girish Thunga; Surulivelrajan Mallayasamy Journal: Osong Public Health Res Perspect Date: 2018-08
Authors: Aida Jiménez-Corona; Antonio Ávila-Hermosillo; Robert G Nelson; Guadalupe Ramírez-López Journal: J Diabetes Res Date: 2015-08-11 Impact factor: 4.011