BACKGROUND: Recent studies demonstrate that obesity does not affect survival after kidney transplantation. However, overweight and obesity impair health-related quality of life (HRQOL) in patients with chronic illnesses. We wished to examine the effects of pre-transplant overweight and obesity on post-transplant physical HRQOL in kidney transplant recipients. STUDY DESIGN: Patient-reported HRQOL data were systematically collected in kidney transplant recipients receiving post-transplant follow-up at Vanderbilt Transplant Center. Patients who received kidney transplants between 1998 and 2008, had at least 1 post-transplant physical component summary (PCS) measurement, and did not receive other solid organ transplants were included in this retrospective cohort study. Pre-transplant body mass index was stratified as normal, overweight, obese class I, and obese class II/extremely obese. HRQOL was measured primarily with the PCS scale of the Medical Outcomes Study Short Form 36 Health Survey. Multivariate linear and logistic regression models were used to test the effects of body mass index and demographic and clinical covariates on post-transplant HRQOL. RESULTS: The study cohort included 464 adults (mean body mass index 27.5 +/- 5.1; range 18.5 to 47.4). After controlling for gender (p = 0.148), pre-transplant dialysis (p = 0.003), previous kidney transplantation (p = 0.255), donor type (p = 0.455), steroid avoidance immunosuppression (p = 0.070), and follow-up time (p = 0.352), there was no effect of pre-transplant overweight or obesity on post-transplant PCS (all p > or = 0.112). Kidney transplant recipients who did not require dialysis pre-transplant and those who were managed with steroid avoidance after transplantation were more likely to achieve post-transplant PCS scores at or above the general population average (both p < or = 0.011). CONCLUSIONS: Pre-transplant overweight and obesity do not affect physical quality of life after kidney transplantation. Copyright 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
BACKGROUND: Recent studies demonstrate that obesity does not affect survival after kidney transplantation. However, overweight and obesity impair health-related quality of life (HRQOL) in patients with chronic illnesses. We wished to examine the effects of pre-transplant overweight and obesity on post-transplant physical HRQOL in kidney transplant recipients. STUDY DESIGN:Patient-reported HRQOL data were systematically collected in kidney transplant recipients receiving post-transplant follow-up at Vanderbilt Transplant Center. Patients who received kidney transplants between 1998 and 2008, had at least 1 post-transplant physical component summary (PCS) measurement, and did not receive other solid organ transplants were included in this retrospective cohort study. Pre-transplant body mass index was stratified as normal, overweight, obese class I, and obese class II/extremely obese. HRQOL was measured primarily with the PCS scale of the Medical Outcomes Study Short Form 36 Health Survey. Multivariate linear and logistic regression models were used to test the effects of body mass index and demographic and clinical covariates on post-transplant HRQOL. RESULTS: The study cohort included 464 adults (mean body mass index 27.5 +/- 5.1; range 18.5 to 47.4). After controlling for gender (p = 0.148), pre-transplant dialysis (p = 0.003), previous kidney transplantation (p = 0.255), donor type (p = 0.455), steroid avoidance immunosuppression (p = 0.070), and follow-up time (p = 0.352), there was no effect of pre-transplant overweight or obesity on post-transplant PCS (all p > or = 0.112). Kidney transplant recipients who did not require dialysis pre-transplant and those who were managed with steroid avoidance after transplantation were more likely to achieve post-transplant PCS scores at or above the general population average (both p < or = 0.011). CONCLUSIONS: Pre-transplant overweight and obesity do not affect physical quality of life after kidney transplantation. Copyright 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
Authors: M Z Molnar; E Streja; C P Kovesdy; S Bunnapradist; M S Sampaio; J Jing; M Krishnan; A R Nissenson; G M Danovitch; K Kalantar-Zadeh Journal: Am J Transplant Date: 2011-04 Impact factor: 8.086
Authors: Thomas Prudhomme; Jean Baptiste Beauval; Marine Lesourd; Mathieu Roumiguié; Karel Decaestecker; Graziano Vignolini; Riccardo Campi; Sergio Serni; Angelo Territo; Luis Gausa; Volkan Tugcu; Selcuk Sahin; Antonio Alcaraz; Mireia Musquera; Michael Stockle; Martin Janssen; Paolo Fornara; Nasreldin Mohammed; Arnaud Del Bello; Nassim Kamar; Federico Sallusto; Alberto Breda; Nicolas Doumerc Journal: World J Urol Date: 2020-06-19 Impact factor: 4.226
Authors: Elani Streja; Miklos Z Molnar; Csaba P Kovesdy; Suphamai Bunnapradist; Jennie Jing; Allen R Nissenson; Istvan Mucsi; Gabriel M Danovitch; Kamyar Kalantar-Zadeh Journal: Clin J Am Soc Nephrol Date: 2011-03-17 Impact factor: 8.237
Authors: Rachel C Forbes; Irene D Feurer; David LaNeve; Beatrice P Concepcion; Christianna Gamble; Scott A Rega; C Wright Pinson; David Shaffer Journal: Clin Transplant Date: 2018-03-30 Impact factor: 2.863