OBJECTIVE: To evaluate the effects of strict dietary salt restriction on blood pressure and proteinuria in chronic glomerulonephritis (CGN) patients. METHODS: From October 2007 to April 2009, 32 CGN inpatients were enrolled. Among them, 15 patients followed a strict dietary salt restriction menu (sodium 100 mmol/d, potassium 50 mmol/d, protein (0.8 - 1.0) gxkg(-1)xd(-1), calorie (105 - 125) kJxkg(-1)xd(-1)) for 7 days, while the other 17 patients were fed freely offered by hospital as controls. 24 h urinary sodium excretion (24h-UNa) was used to monitor the salt intake. No changes of drug therapy were made during the study. Blood pressure was monitored every day. 24-hour urinary protein and serum biochemical parameter were measured before and after the study. RESULTS: There was no significant difference of baseline 24h-UNa between the two groups [(135.1 +/- 50.4) mmol/d vs (137.4 +/- 28.6) mmol/d)]. During the study, the average 24h-UNa of patients with strict dietary intervention was (97.2 +/- 8.6) mmol/d. Both SBP [(117.7 +/- 10.0) mm Hg (1 mm Hg = 0.133 kPa) vs (106.2 +/- 9.9) mm Hg] and DBP [(76.3 +/- 6.1) mm Hg vs (67.5 +/- 5.5) mm Hg] decreased significantly (P < 0.001). Proteinuria decreased significantly too [1.57 (0.3 - 3.0) g/d vs 0.57 (0.16 - 2.72) g/d, P = 0.006]. The reduction of SBP was positively correlated with the reduction of 24h-UNa (r = 0.572, P = 0.026), while the reduction of proteinuria correlated with both the reduction of SBP (r = 0.568, P = 0.027) and 24h-UNa (r = 0.525, P = 0.044). In the control group, only SBP decreased significantly [(122.6 +/- 15.5) mm Hg vs (115.8 +/- 10.4) mm Hg, P = 0.02] without significant changes of DBP and proteinuria. When comparing the subgroups who took ACEI/ARB from both groups, the reduction of proteinuria was more prominent of those from the study group than the control group [-0.4(-0.95 - 0.07) vs 0.07(-0.39 - 0.42), P = 0.014]. CONCLUSION: Strict dietary salt restriction is effective in reducing blood pressure and proteinuria in CGN patients.
OBJECTIVE: To evaluate the effects of strict dietary salt restriction on blood pressure and proteinuria in chronic glomerulonephritis (CGN) patients. METHODS: From October 2007 to April 2009, 32 CGN inpatients were enrolled. Among them, 15 patients followed a strict dietary salt restriction menu (sodium 100 mmol/d, potassium 50 mmol/d, protein (0.8 - 1.0) gxkg(-1)xd(-1), calorie (105 - 125) kJxkg(-1)xd(-1)) for 7 days, while the other 17 patients were fed freely offered by hospital as controls. 24 h urinary sodium excretion (24h-UNa) was used to monitor the salt intake. No changes of drug therapy were made during the study. Blood pressure was monitored every day. 24-hour urinary protein and serum biochemical parameter were measured before and after the study. RESULTS: There was no significant difference of baseline 24h-UNa between the two groups [(135.1 +/- 50.4) mmol/d vs (137.4 +/- 28.6) mmol/d)]. During the study, the average 24h-UNa of patients with strict dietary intervention was (97.2 +/- 8.6) mmol/d. Both SBP [(117.7 +/- 10.0) mm Hg (1 mm Hg = 0.133 kPa) vs (106.2 +/- 9.9) mm Hg] and DBP [(76.3 +/- 6.1) mm Hg vs (67.5 +/- 5.5) mm Hg] decreased significantly (P < 0.001). Proteinuria decreased significantly too [1.57 (0.3 - 3.0) g/d vs 0.57 (0.16 - 2.72) g/d, P = 0.006]. The reduction of SBP was positively correlated with the reduction of 24h-UNa (r = 0.572, P = 0.026), while the reduction of proteinuria correlated with both the reduction of SBP (r = 0.568, P = 0.027) and 24h-UNa (r = 0.525, P = 0.044). In the control group, only SBP decreased significantly [(122.6 +/- 15.5) mm Hg vs (115.8 +/- 10.4) mm Hg, P = 0.02] without significant changes of DBP and proteinuria. When comparing the subgroups who took ACEI/ARB from both groups, the reduction of proteinuria was more prominent of those from the study group than the control group [-0.4(-0.95 - 0.07) vs 0.07(-0.39 - 0.42), P = 0.014]. CONCLUSION: Strict dietary salt restriction is effective in reducing blood pressure and proteinuria in CGN patients.