Literature DB >> 20192242

Gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glucosides, from the bark of Gnetum gnemonoides.

Yoko Shimokawa1, Yusuke Akao, Yusuke Hirasawa, Khalijah Awang, A Hamid A Hadi, Seizo Sato, Chihiro Aoyama, Jiro Takeo, Motoo Shiro, Hiroshi Morita.   

Abstract

Gneyulins A (1) and B (2), two new stilbene trimers consisting of oxyresveratrol constituent units, and noidesols A (3) and B (4), two new dihydroflavonol-C-glucosides, were isolated from the bark of Gnetum gnemonoides. The structures and configurations of 1-4 were elucidated on the basis of 2D NMR correlations and X-ray analysis. Gneyulins A (1) and B (2) showed inhibition of Na(+)-glucose transporters (SGLT-1 and SGLT-2).

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Year:  2010        PMID: 20192242     DOI: 10.1021/np9007987

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  4 in total

1.  Molecular mechanism of vSGLT inhibition by gneyulin reveals antiseptic properties against multidrug-resistant gram-negative bacteria.

Authors:  Daniel Wiczew; Anna Borowska; Kinga Szkaradek; Tomasz Biegus; Kamil Wozniak; Marcelina Pyclik; Magdalena Sitarska; Lukasz Jaszewski; Lukasz Radosinski; Beata Hanus-Lorenz; Sebastian Kraszewski
Journal:  J Mol Model       Date:  2019-06-11       Impact factor: 1.810

2.  Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs.

Authors:  Mutaib M Mashraqi; Navaneet Chaturvedi; Qamre Alam; Saleh Alshamrani; Mosa M Bahnass; Khurshid Ahmad; Amany I Alqosaibi; Mashael M Alnamshan; Syed Sayeed Ahmad; Mirza Masroor Ali Beg; Abha Mishra; Sibhghatulla Shaikh; Syed Mohd Danish Rizvi
Journal:  Molecules       Date:  2021-01-22       Impact factor: 4.411

Review 3.  SGLT inhibitors as antidiabetic agents: a comprehensive review.

Authors:  Rahul P Kshirsagar; Abhishek A Kulkarni; Rashmi S Chouthe; Shahebaaz K Pathan; Hemant D Une; G Bhanuprakash Reddy; Prakash V Diwan; Siddique Akber Ansari; Jaiprakash N Sangshetti
Journal:  RSC Adv       Date:  2020-01-09       Impact factor: 4.036

Review 4.  Phytochemicals as Regulators of Tumor Glycolysis and Hypoxia Signaling Pathways: Evidence from In Vitro Studies.

Authors:  Ioana-Ecaterina Pralea; Alina-Maria Petrache; Adrian Bogdan Tigu; Diana Gulei; Radu-Cristian Moldovan; Maria Ilieș; Raul Nicoară; Simona-Codruța Hegheș; Alina Uifălean; Cristina-Adela Iuga
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-28
  4 in total

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