| Literature DB >> 20192183 |
Wei Zhang1, Suqing Zheng, Na Liu, Jenny B Werness, Ilia A Guzei, Weiping Tang.
Abstract
A catalytic enantioselective syn-1,4-bromolactonization of conjugated (Z)-enynes was reported. Diastereomeric ratios >20:1 and up to 99% enantiomeric excesses were observed. Di-, tri-, and tetra-substituted bromoallenes were prepared together with lactone heterocycles efficiently and stereoselectively. Preliminary investigations suggest that the chiral catalyst may serve as a bifunctional reagent by interacting with both a carboxylic acid nucleophile and NBS electrophile.Entities:
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Year: 2010 PMID： 20192183 DOI： 10.1021/ja100173w
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419