OBJECTIVE:Magnetic resonance imaging (MRI) is sensitive for scoring inflammatory lesions in the spine, but attention has primarily focused on vertebral bodies, and no study has systematically examined the posterior elements. We aimed to systematically determine the frequency and distribution of inflammatory changes in the posterior elements of the spine using MRI, and to assess the reliability of their detection and their impact on discrimination of spinal MRI. METHODS: We scanned 32 patients recruited to placebo-controlled trials of anti-tumor necrosis factor therapy. Inflammatory lesions were detected by systematic review of consecutive sagittal STIR slices of the entire spine. Two readers evaluated pretreatment and posttreatment scans, blinded to treatment and time point. Inflammation was scored dichotomously (present/absent) in each posterior structure. Reproducibility was assessed by calculating random model variance components and generalizability coefficients, and discrimination by using Guyatt's effect size. RESULTS: Most patients (87.5%) had > or =1 lesion in the posterior elements (mean +/- SD number of affected spinal levels per patient 6.7 +/- 5.3), and they were detected most frequently in the thoracic spine. Interobserver reproducibility for total lesion count was very good to excellent for lesions in the thoracic spine and transverse and spinous processes. The addition of a simple dichotomous method for scoring posterior element inflammation substantially enhanced the discrimination observed using established MRI methods for scoring vertebral body inflammation. CONCLUSION:Inflammatory lesions in the posterior elements were present in the majority of patients with AS, and standard MRI protocols of the spine should be modified to ensure adequate visualization of posterolateral structures.
RCT Entities:
OBJECTIVE: Magnetic resonance imaging (MRI) is sensitive for scoring inflammatory lesions in the spine, but attention has primarily focused on vertebral bodies, and no study has systematically examined the posterior elements. We aimed to systematically determine the frequency and distribution of inflammatory changes in the posterior elements of the spine using MRI, and to assess the reliability of their detection and their impact on discrimination of spinal MRI. METHODS: We scanned 32 patients recruited to placebo-controlled trials of anti-tumornecrosis factor therapy. Inflammatory lesions were detected by systematic review of consecutive sagittal STIR slices of the entire spine. Two readers evaluated pretreatment and posttreatment scans, blinded to treatment and time point. Inflammation was scored dichotomously (present/absent) in each posterior structure. Reproducibility was assessed by calculating random model variance components and generalizability coefficients, and discrimination by using Guyatt's effect size. RESULTS: Most patients (87.5%) had > or =1 lesion in the posterior elements (mean +/- SD number of affected spinal levels per patient 6.7 +/- 5.3), and they were detected most frequently in the thoracic spine. Interobserver reproducibility for total lesion count was very good to excellent for lesions in the thoracic spine and transverse and spinous processes. The addition of a simple dichotomous method for scoring posterior element inflammation substantially enhanced the discrimination observed using established MRI methods for scoring vertebral body inflammation. CONCLUSION: Inflammatory lesions in the posterior elements were present in the majority of patients with AS, and standard MRI protocols of the spine should be modified to ensure adequate visualization of posterolateral structures.
Authors: Martina Karpitschka; Patrizia Godau-Kellner; Herbert Kellner; Annie Horng; Daniel Theisen; Christian Glaser; Bernhard Brandlhuber; Maximilian Reiser; Sabine Weckbach Journal: Eur Radiol Date: 2013-03-15 Impact factor: 5.315
Authors: Sovira Tan; Abhijit Dasgupta; Jianhua Yao; John A Flynn; Lawrence Yao; Michael M Ward Journal: Ann Rheum Dis Date: 2016-01-21 Impact factor: 19.103
Authors: Dorothee R Fischer; Christian W A Pfirrmann; Veronika Zubler; Katrin D M Stumpe; Burkhardt Seifert; Klaus Strobel; Giorgio Tamborrini; Gustav K von Schulthess; Beat A Michel; Adrian Ciurea Journal: EJNMMI Res Date: 2012-07-12 Impact factor: 3.138