| Literature DB >> 20191346 |
Hee Wook Park1, Jae Hyeok Lee, Sang-Un Choi, Nam-In Baek, Sung-Hoon Kim, Jae Heon Yang, Dae Keun Kim.
Abstract
A new (3) and three known germacrane-type sesquiterpenoids were isolated from the chloroform-soluble fraction of the methanolic extract of the bark of Magnolia kobus (Magnoliaceae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as costunolide (1), parthenolide (2), isobisparthenolidine (3), and bisparthenolidine (4) by spectroscopic analysis. Compounds 1-4 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.Entities:
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Year: 2010 PMID： 20191346 DOI： 10.1007/s12272-010-2227-5
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946