Literature DB >> 20190864

Do viruses use vectors to penetrate mucus barriers?

Katharina Ribbeck1.   

Abstract

I propose a mechanism by which viruses successfully infect new individuals, despite being immotile particles with no ability for directed movement. Within cells, viral particle movements are directed by motors and elements of the cytoskeleton, but how viruses cross extracellular barriers, like mucus, remains a mystery. I propose that viruses cross these barriers by hitch-hiking on bacteria or sperm cells which can transport themselves across mucosal layers designed to protect the underlying cells from pathogen attack. An important implication of this hypothesis is that agents that block interactions between viruses and bacteria or sperm may be new tools for disease prevention.

Entities:  

Year:  2009        PMID: 20190864      PMCID: PMC2826788          DOI: 10.1016/j.bihy.2009.07.004

Source DB:  PubMed          Journal:  Biosci Hypotheses        ISSN: 1876-746X


  23 in total

1.  Determination of the proteins and capsids of herpes simplex virus in human spermatozoa.

Authors:  E N Bocharova; R A Abdumalikov; E E Bragina; R R Klimova; S M Adueva; M G Medzhidova; L F Kurilo; A A Kushch
Journal:  Dokl Biol Sci       Date:  2003 Jul-Aug

Review 2.  Sperm transport in the female reproductive tract.

Authors:  S S Suarez; A A Pacey
Journal:  Hum Reprod Update       Date:  2005-11-04       Impact factor: 15.610

Review 3.  Barrier properties of mucus.

Authors:  Richard A Cone
Journal:  Adv Drug Deliv Rev       Date:  2008-12-16       Impact factor: 15.470

4.  Transovarial transmission of yellow fever virus by mosquitoes (Aedes aegypti).

Authors:  T H Aitken; R B Tesh; B J Beaty; L Rosen
Journal:  Am J Trop Med Hyg       Date:  1979-01       Impact factor: 2.345

5.  Binding of Haemophilus influenzae to purified mucins from the human respiratory tract.

Authors:  J Davies; I Carlstedt; A K Nilsson; A Håkansson; H Sabharwal; L van Alphen; M van Ham; C Svanborg
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441

6.  Adsorption to fish sperm of vertically transmitted fish viruses.

Authors:  D Mulcahy; R J Pascho
Journal:  Science       Date:  1984-07-20       Impact factor: 47.728

7.  Resting B cells as a transfer vehicle for Epstein-Barr virus infection of epithelial cells.

Authors:  C D Shannon-Lowe; B Neuhierl; G Baldwin; A B Rickinson; H-J Delecluse
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-10       Impact factor: 11.205

8.  Binding of staphylococci to mucus in vivo and in vitro.

Authors:  B A Sanford; V L Thomas; M A Ramsay
Journal:  Infect Immun       Date:  1989-12       Impact factor: 3.441

9.  Group A streptococci bind to mucin and human pharyngeal cells through sialic acid-containing receptors.

Authors:  P A Ryan; V Pancholi; V A Fischetti
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

10.  Frequency of herpes simplex virus, cytomegalovirus and human papillomavirus DNA in semen.

Authors:  Olivier Aynaud; Jean-Dominique Poveda; Bernard Huynh; Aline Guillemotonia; Renzo Barrasso
Journal:  Int J STD AIDS       Date:  2002-08       Impact factor: 1.359

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