Literature DB >> 20190829

p62, an autophagy hero or culprit?

Tor Erik Rusten1, Harald Stenmark.   

Abstract

The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease.

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Year:  2010        PMID： 20190829     DOI： 10.1038/ncb0310-207

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  9 in total

1.  Loss of autophagy in the central nervous system causes neurodegeneration in mice.

Authors:  Masaaki Komatsu; Satoshi Waguri; Tomoki Chiba; Shigeo Murata; Jun-ichi Iwata; Isei Tanida; Takashi Ueno; Masato Koike; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka
Journal:  Nature       Date:  2006-04-19       Impact factor: 49.962

2.  Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Authors:  Masaaki Komatsu; Satoshi Waguri; Masato Koike; Yu-Shin Sou; Takashi Ueno; Taichi Hara; Noboru Mizushima; Jun-Ichi Iwata; Junji Ezaki; Shigeo Murata; Jun Hamazaki; Yasumasa Nishito; Shun-Ichiro Iemura; Tohru Natsume; Toru Yanagawa; Junya Uwayama; Eiji Warabi; Hiroshi Yoshida; Tetsuro Ishii; Akira Kobayashi; Masayuki Yamamoto; Zhenyu Yue; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582

3.  NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.

Authors:  Trond Lamark; Vladimir Kirkin; Ivan Dikic; Terje Johansen
Journal:  Cell Cycle       Date:  2009-07-30       Impact factor: 4.534

4.  A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Authors:  Vladimir Kirkin; Trond Lamark; Yu-Shin Sou; Geir Bjørkøy; Jennifer L Nunn; Jack-Ansgar Bruun; Elena Shvets; David G McEwan; Terje H Clausen; Philipp Wild; Ivana Bilusic; Jean-Philippe Theurillat; Aud Øvervatn; Tetsuro Ishii; Zvulun Elazar; Masaaki Komatsu; Ivan Dikic; Terje Johansen
Journal:  Mol Cell       Date:  2009-02-27       Impact factor: 17.970

5.  The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Authors:  Masaaki Komatsu; Hirofumi Kurokawa; Satoshi Waguri; Keiko Taguchi; Akira Kobayashi; Yoshinobu Ichimura; Yu-Shin Sou; Izumi Ueno; Ayako Sakamoto; Kit I Tong; Mihee Kim; Yasumasa Nishito; Shun-ichiro Iemura; Tohru Natsume; Takashi Ueno; Eiki Kominami; Hozumi Motohashi; Keiji Tanaka; Masayuki Yamamoto
Journal:  Nat Cell Biol       Date:  2010-02-21       Impact factor: 28.824

6.  Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.

Authors:  Tom Luedde; Naiara Beraza; Vasileios Kotsikoris; Geert van Loo; Arianna Nenci; Rita De Vos; Tania Roskams; Christian Trautwein; Manolis Pasparakis
Journal:  Cancer Cell       Date:  2007-02       Impact factor: 31.743

7.  The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

Authors:  Lufen Chang; Hideaki Kamata; Giovanni Solinas; Jun-Li Luo; Shin Maeda; K Venuprasad; Yun-Cai Liu; Michael Karin
Journal:  Cell       Date:  2006-02-10       Impact factor: 41.582

8.  Autophagy suppresses tumorigenesis through elimination of p62.

Authors:  Robin Mathew; Cristina M Karp; Brian Beaudoin; Nhan Vuong; Guanghua Chen; Hsin-Yi Chen; Kevin Bray; Anupama Reddy; Gyan Bhanot; Celine Gelinas; Robert S Dipaola; Vassiliki Karantza-Wadsworth; Eileen White
Journal:  Cell       Date:  2009-06-12       Impact factor: 41.582

9.  Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.

Authors:  Ioannis P Nezis; Anne Simonsen; Antonia P Sagona; Kim Finley; Sébastien Gaumer; Didier Contamine; Tor Erik Rusten; Harald Stenmark; Andreas Brech
Journal:  J Cell Biol       Date:  2008-03-17       Impact factor: 10.539
  9 in total
  97 in total

1.  Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.

Authors:  Adrian Rubio-González; Juan Carlos Bermejo-Millo; Beatriz de Luxán-Delgado; Yaiza Potes; Zulema Pérez-Martínez; José Antonio Boga; Ignacio Vega-Naredo; Beatriz Caballero; Juan José Solano; Ana Coto-Montes
Journal:  Mol Neurobiol       Date:  2017-10-30       Impact factor: 5.590

2.  Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2.

Authors:  Ji Jiang; Lok Ming Tam; Pengcheng Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2018-04-23       Impact factor: 3.739

3.  Attenuating oxygen-glucose deprivation-caused autophagosome accumulation may be involved in sevoflurane postconditioning-induced protection in human neuron-like cells.

Authors:  Aobing Cheng; Yang Lu; Qiaobing Huang; Zhiyi Zuo
Journal:  Eur J Pharmacol       Date:  2019-01-30       Impact factor: 4.432

4.  STUB1 regulates TFEB-induced autophagy-lysosome pathway.

Authors:  Youbao Sha; Lang Rao; Carmine Settembre; Andrea Ballabio; N Tony Eissa
Journal:  EMBO J       Date:  2017-07-28       Impact factor: 11.598

Review 5.  Relevance of autophagy to fatty liver diseases and potential therapeutic applications.

Authors:  Shengmin Yan; Nazmul Huda; Bilon Khambu; Xiao-Ming Yin
Journal:  Amino Acids       Date:  2017-05-06       Impact factor: 3.520

6.  Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.

Authors:  Meysam Yazdankhah; Peng Shang; Sayan Ghosh; Imran A Bhutto; Nadezda Stepicheva; Rhonda Grebe; Stacey Hose; Joseph Weiss; Tianqi Luo; Subrata Mishra; S Amer Riazuddin; Arkasubhra Ghosh; James T Handa; Gerard A Lutty; J Samuel Zigler; Debasish Sinha
Journal:  Autophagy       Date:  2019-09-01       Impact factor: 16.016

7.  Targeting Autophagy Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib.

Authors:  Weibin Wang; Helen Kang; Yinu Zhao; Irene Min; Brian Wyrwas; Maureen Moore; Lisong Teng; Rasa Zarnegar; Xuejun Jiang; Thomas J Fahey
Journal:  J Clin Endocrinol Metab       Date:  2017-02-01       Impact factor: 5.958

8.  Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

Authors:  Neeraj K Saini; Andres Baena; Tony W Ng; Manjunatha M Venkataswamy; Steven C Kennedy; Shajo Kunnath-Velayudhan; Leandro J Carreño; Jiayong Xu; John Chan; Michelle H Larsen; William R Jacobs; Steven A Porcelli
Journal:  Nat Microbiol       Date:  2016-08-15       Impact factor: 17.745

9.  Impaired autophagic function in rat islets with aging.

Authors:  Yu Liu; Suozhu Shi; Zhaoyan Gu; Yingzhen Du; Minyan Liu; Shuangtong Yan; Jianjun Gao; Jian Li; Yinghong Shao; Wenwen Zhong; Xiangmei Chen; Chunlin Li
Journal:  Age (Dordr)       Date:  2012-07-28

10.  p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells.

Authors:  Johanna Viiri; Juha M T Hyttinen; Tuomas Ryhänen; Kirsi Rilla; Tuomas Paimela; Erkki Kuusisto; Ari Siitonen; Arto Urtti; Antero Salminen; Kai Kaarniranta
Journal:  Mol Vis       Date:  2010-07-27       Impact factor: 2.367
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