D Tong1, J Deng, H Sun, L Chen, X Wu. 1. Department of Forensic Medicine, Zhongshan Medical College, Sun Yat-sen University, 510080, Guangzhou, China.
Abstract
OBJECTIVE: To research the relationship between polymorphism of trinucleotide (CAG)n repeat alleles of the Exon 1 of androgen receptor gene and women with polycystic ovary syndrome (PCOS), or with endometriosis. MATERIALS AND METHODS: One hundred and forty-one control women and 74 women with PCOS and with endometriosis were recruited. The (CAG)n repeat alleles were genotyped with 3100 genetic analyser. The repeat number and frequency distributions of (CAG)n alleles were compared and analyzed statistically. RESULTS: The results showed that mean repeat number of the (CAG)n was significantly lower in women with PCOS than in controls (p<0.001). The mean repeat number of the (CAG)n was significantly different between infertile women with endometriosis (p<0.05). However, the differences between infertile women with PCOS and fertile women with PCOS was not significant (p>0.05). CONCLUSIONS: These data indicated that (CAG)n repeat polymorphism have some influence, but have not a straight relationship in infertile women with PCOS and with endometriosis in this research population.
OBJECTIVE: To research the relationship between polymorphism of trinucleotide (CAG)n repeat alleles of the Exon 1 of androgen receptor gene and women with polycystic ovary syndrome (PCOS), or with endometriosis. MATERIALS AND METHODS: One hundred and forty-one control women and 74 women with PCOS and with endometriosis were recruited. The (CAG)n repeat alleles were genotyped with 3100 genetic analyser. The repeat number and frequency distributions of (CAG)n alleles were compared and analyzed statistically. RESULTS: The results showed that mean repeat number of the (CAG)n was significantly lower in women with PCOS than in controls (p<0.001). The mean repeat number of the (CAG)n was significantly different between infertile women with endometriosis (p<0.05). However, the differences between infertile women with PCOS and fertile women with PCOS was not significant (p>0.05). CONCLUSIONS: These data indicated that (CAG)n repeat polymorphism have some influence, but have not a straight relationship in infertile women with PCOS and with endometriosis in this research population.
Authors: Helen E MacLean; Robert W Brown; Jonathan Beilin; Garry L Warne; Jeffrey D Zajac Journal: Breast Cancer Res Treat Date: 2004-12 Impact factor: 4.872
Authors: M Urbanek; R S Legro; D A Driscoll; R Azziz; D A Ehrmann; R J Norman; J F Strauss; R S Spielman; A Dunaif Journal: Proc Natl Acad Sci U S A Date: 1999-07-20 Impact factor: 11.205
Authors: Kirsi Syrjäkoski; Eija-R Hyytinen; Tuula Kuukasjärvi; Anssi Auvinen; Olli-P Kallioniemi; Tommi Kainu; Pasi A Koivisto Journal: Breast Cancer Res Treat Date: 2003-01 Impact factor: 4.872
Authors: Filip Van Nieuwerburgh; Dominic Stoop; Patrick Cabri; Marc Dhont; Dieter Deforce; Petra De Sutter Journal: Gynecol Endocrinol Date: 2008-12 Impact factor: 2.260