Literature DB >> 20190316

Limb salvage for soft-tissue sarcomas of the foot and ankle.

G L Cribb1, S C S Loo, I Dickinson.   

Abstract

We evaluated the oncological and functional outcome of 27 patients who had limb salvage for a soft-tissue sarcoma of the foot or ankle between 1992 and 2007, with a mean follow-up of 7.5 years (1.05 to 16.2). There were 12 men and 15 women, with a mean age at presentation of 47 years (12 to 84). Referrals came from other hospitals for 16 patients who had previous biopsy or unplanned excision, and 11 presented de novo. There were 18 tumours located in the foot and nine around the ankle. Synovial sarcoma was the most frequent histological diagnosis. Excision was performed in all cases, with 16 patients requiring plastic surgical reconstruction with 13 free and three local flaps. Adjuvant treatment was undertaken in 20 patients, 18 with radiotherapy and two by chemotherapy. Limb salvage was successful in 26 of the 27 patients. There have been two local recurrences and two mesenchymal metastases. Four patients have died of their sarcoma and two of other causes. Function was evaluated with the Toronto Extremity Salvage Score and a mean overall score of 89.40 (52.1 to 100) was obtained. A questionnaire revealed that all surviving patients are able to wear normal shoes and none require a walking aid. Limb salvage can achieve good oncological and functional results with additional treatment.

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Year:  2010        PMID: 20190316     DOI: 10.1302/0301-620X.92B3.22331

Source DB:  PubMed          Journal:  J Bone Joint Surg Br        ISSN: 0301-620X


  5 in total

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2.  The adverse effect of an unplanned surgical excision of foot soft tissue sarcoma.

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3.  Malignant tumours of the foot and ankle.

Authors:  E Mascard; N Gaspar; L Brugières; C Glorion; S Pannier; A Gomez-Brouchet
Journal:  EFORT Open Rev       Date:  2017-05-11

4.  A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response.

Authors:  Donghai Xiong; Yian Wang; Ming You
Journal:  Nat Commun       Date:  2020-10-08       Impact factor: 14.919

5.  Soft tissue sarcoma affecting the right shoulder of a man with paraplegia from a remote traumatic spinal cord injury: a case report.

Authors:  Colin K Franz; Kyriakos Dalamagkas; Lewis A Jordan; Gayle R Spill
Journal:  Spinal Cord Ser Cases       Date:  2018-06-26
  5 in total

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