| Literature DB >> 20189883 |
Masahiko Ito1, Kyoko Murakami, Tetsuro Suzuki, Keiko Mochida, Miho Suzuki, Kenji Ikebuchi, Kazunari Yamaguchi, Toshiaki Mizuochi.
Abstract
Epidemiological data indicate a close relationship between chronic hepatitis C virus (HCV) infection and B-cell non-Hodgkin's lymphoma (B-NHL), suggesting that chronic HCV infection is, at least in part, associated with B-lymphomagenesis. However, experimental data concerning these conditions remains elusive. In this study, we confirmed that peripheral blood B cells of chronic hepatitis C (CHC) patients were infected with HCV. Expression levels of activation-induced cytidine deaminase (AID) which are thought to be associated with occurrence of B-NHL were analyzed in these CHC B cells. It was demonstrated that AID mRNA/protein levels in CHC B cells were dramatically increased compared with those of healthy subjects. Furthermore, expression levels of several previously reported prognostic B-NHL marker genes in the B cell subset of CHC patients were increased. These results suggest a possible relationship between chronic HCV infection and B-lymphomagenesis. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20189883 DOI： 10.1016/j.clim.2010.02.002
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969