| Literature DB >> 20189453 |
Isabel R Orriss1, Geoffrey Burnstock, Timothy R Arnett.
Abstract
Accumulating evidence suggests that extracellular nucleotides, signalling through P2 receptors, could play an important role in modulating bone cell function. ATP and other nucleotides can stimulate the formation and resorptive activity of osteoclasts (bone-destroying cells) in addition to inhibiting bone mineralisation by osteoblasts. This review discusses the current understanding of the effects of extracellular nucleotides on skeletal cells. Copyright 2010. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID: 20189453 DOI: 10.1016/j.coph.2010.01.003
Source DB: PubMed Journal: Curr Opin Pharmacol ISSN: 1471-4892 Impact factor: 5.547