Literature DB >> 20188664

The case of the disappearing drug target.

John T Prince1, Natalie G Ahn.   

Abstract

In this issue of Molecular Cell, Hoshi et al. (2010) report two examples in which small molecule inhibitors are rendered ineffective when their kinase targets are involved in protein-protein interactions, highlighting differences between in vivo and in vitro inhibition kinetics. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20188664     DOI: 10.1016/j.molcel.2010.02.010

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  5 in total

Review 1.  Local cAMP signaling in disease at a glance.

Authors:  Matthew G Gold; Tamir Gonen; John D Scott
Journal:  J Cell Sci       Date:  2013-10-15       Impact factor: 5.285

Review 2.  Signal integration through blending, bolstering and bifurcating of intracellular information.

Authors:  Catherine T Pawson; John D Scott
Journal:  Nat Struct Mol Biol       Date:  2010-05-23       Impact factor: 15.369

3.  Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220.

Authors:  Jennifer L Whiting; Patrick J Nygren; Brian J Tunquist; Lorene K Langeberg; Ole-Morten Seternes; John D Scott
Journal:  J Biol Chem       Date:  2015-06-18       Impact factor: 5.157

4.  STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.

Authors:  Tuoping Luo; Kristina Masson; Jacob D Jaffe; Whitney Silkworth; Nathan T Ross; Christina A Scherer; Claudia Scholl; Stefan Fröhling; Steven A Carr; Andrew M Stern; Stuart L Schreiber; Todd R Golub
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-09       Impact factor: 11.205

Review 5.  Creating order from chaos: cellular regulation by kinase anchoring.

Authors:  John D Scott; Carmen W Dessauer; Kjetil Taskén
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012-10-08       Impact factor: 13.820

  5 in total

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